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Community health status and long-term outcomes in 1-year survivors of autologous and allogeneic hematopoietic cell transplantation

Bone Marrow Transplantation volume 57, pages 671–673 (2022)Cite this article

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Hematopoietic cell transplantation (HCT) is a potentially curative, but expensive and resource-intensive, therapy for patients with various hematologic diseases [1, 2]. Many social determinants of health, including age, race/ethnicity, insurance status, and socioeconomic status, have been described in the transplant literature, demonstrating their impact on access to and outcomes of HCT [3,4,5,6,7,8,9]. Individual factors such as race and income, however, likely do not fully explain the health disparities surrounding HCT. While patients are well-supported and monitored during the first 3–6 months after transplant while they reside near the hospital, they may face a host of challenges once they return to their residence in their long-term recovery from a complex procedure such as HCT.

The County Health Rankings and Roadmaps (CHRR) is a program that provides publicly available data to build awareness of the multiple social factors that influence health. The CHRR uses a database of county-level factors to describe the health disparities of a community [10], including physical environment, social and economic factors, clinical care, and health behaviors. The score obtained from the CHRR model describing a community’s health has been used to study outcomes of solid organ transplants and HCT [3].

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Fig. 1: State-wide distribution of patient residence for HCT recipients.

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Funding

Navneet Majhail is partially supported by a grant from the National Cancer Institute (R01-CA215134).

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Authors and Affiliations

  1. Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

    Julia H. Joo

  2. Department of Hematology and Oncology, Seidman Cancer Center, University Hospital Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA

    Sanghee Hong

  3. Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Lisa A. Rybicki

  4. Blood and Marrow Transplant Program, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA

    Betty K. Hamilton

  5. Sarah Cannon, Nashville, TN, USA

    Navneet S. Majhail

Authors
  1. Julia H. Joo
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  2. Sanghee Hong
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  4. Betty K. Hamilton
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  5. Navneet S. Majhail
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Contributions

JHJ designed and wrote the protocol for the study, interpreted results, created summary tables, and wrote the manuscript. SH contributed ideas for protocol design, interpreted results, and provided feedback to the manuscript. LAR conducted the statistical analysis, interpreted results, created the map figures, and wrote the methods part of the manuscript. BKH provided feedback to the manuscript. NSM designed the protocol, interpreted results, and provided feedback to the manuscript.

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Correspondence to Navneet S. Majhail.

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Joo, J.H., Hong, S., Rybicki, L.A. et al. Community health status and long-term outcomes in 1-year survivors of autologous and allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 57, 671–673 (2022). https://doi.org/10.1038/s41409-022-01602-z

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