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Long-term skin findings in patients with Fanconi anemia after allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 56, pages 2866–2868 (2021)Cite this article

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Hematopoietic stem cell transplantation (HSCT) is the only therapeutic option that can restore normal hematopoiesis in patients with Fanconi anemia (FA) [1]; however, FA patients that undergo HSCT are at risk for long-term complications due to transplant-related factors or due to secondary FA-related issues unrelated to transplantation, including complications of congenital anomalies, endocrinopathies, and an increase in cancer susceptibility [2, 3]. As such, recent guidelines recommend post-HSCT skin cancer screening in FA patients every 6–12 months [4].

This single-center, cross-sectional study aimed to present the outcomes and long-term skin findings of 18 FA patients that underwent allogeneic HSCT at Hacettepe University, Ankara, Turkey, between 2006 and December 2016, so as to make recommendations for dermatologists following-up such patients. Patients were followed-up by a multidisciplinary team at the Pediatric Bone Marrow Transplantation Unit, including experienced specialists of dermatology, ophthalmology, otolaryngology, urology, endocrinology, nephrology, gastroenterology, and cardiology. The study protocol was approved by the Institutional Ethical Committee, and all patients or their legal guardians provided written informed consent.

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Fig. 1: The photographs of the patients and details are given below.

References

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Author information

Authors and Affiliations

  1. Department of Dermatology and Venereology, School of Medicine, Hacettepe University, Ankara, Turkey

    Neslihan Akdogan & Sibel Ersoy-Evans

  2. Division of Pediatric Hematology and Bone Marrow Transplantation Unit, Department of Pediatrics, School of Medicine, Hacettepe University, Ankara, Turkey

    Fatma Visal Okur, Baris Kuskonmaz & Duygu Uckan Cetinkaya

Authors
  1. Neslihan Akdogan
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  2. Sibel Ersoy-Evans
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  3. Fatma Visal Okur
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  4. Baris Kuskonmaz
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  5. Duygu Uckan Cetinkaya
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Contributions

NA, SE-E, and FVO contributed to the study’s conception and design, and critically revised the manuscript. NA, SE-E, FVO, DUC, and BK contributed to collection of patient data and reviewed the manuscript. NA acquired the data, conducted the statistical analysis, and drafted the manuscript; she is the study guarantor.

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Correspondence to Neslihan Akdogan.

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The authors declare no competing interests.

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Akdogan, N., Ersoy-Evans, S., Visal Okur, F. et al. Long-term skin findings in patients with Fanconi anemia after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 56, 2866–2868 (2021). https://doi.org/10.1038/s41409-021-01441-4

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  • DOI: https://doi.org/10.1038/s41409-021-01441-4

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