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Differential microRNAs expression in acute graft-versus-host disease as potential diagnostic biomarkers

Bone Marrow Transplantation volume 55, pages 2339–2342 (2020)Cite this article

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Allogeneic hematopoietic stem cell transplants (allo-HSCTs) are used to treat hematological diseases such as bone marrow failure syndromes, lymphoma, and leukemia. Successful treatment of allo-HSCTs is reduced by graft-versus-host-disease (GVHD), in which donor T cells cause damage to the liver, gastrointestinal tract, and skin [1]. According to the National Institutes of Health (NIH) classification, acute GVHD (aGVHD) occurs within the first 100 days after post-HSCT in the absence of specific features or diagnosis of chronic GVHD (cGVHD) [2]. Despite the fact that aGVHD is the most common post-HSCT complication, there are no early validated diagnostic tests or predictive markers for aGVHD. Thus, identification of noninvasive biomarkers is necessary to predict the risk of aGVHD and the patient overall survival. Previous studies have identified several proteins associated with aGVHD. A 2-biomarker model using ST2 and REG3α concentrations at day 7 after HSCT identified a group of patients at high risk for lethal GVHD and nonrelapse mortality [3]. However, protein biomarkers do not distinguish between aGVHD and other inflammatory conditions [4].

In the current study, we identified a group of microRNAs at the discovery stage that had significant expression differences in plasma aGVHD patients compared with pre-transplant patients.

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Fig. 1: Discovery and validation of miRNA diagnostic biomarkers in aGVHD.

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Acknowledgements

This study was supported by grants from Dr. Marjan Yaghmaie (Grant# 95-04-36-33688) and Dr. Mohammad Ahmadvand from Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. This study was part of the Ph.D dissertation of Jamshid Motaei (Mashhad University of Medical Sciences, Mashhad, Iran, and Proposal No. 971083).

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Authors and Affiliations

  1. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

    Jamshid Motaei

  2. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Jamshid Motaei, Marjan Yaghmaie, Hossein Pashaiefar, Seyed Asadollah Mousavi, Ardeshir Ghavamzadeh & Mohammad Ahmadvand

  3. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Jamshid Motaei & Mohammad Amin Kerachian

  4. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Jamshid Motaei & Mohammad Amin Kerachian

  5. Cancer Genetics Research Unit, Reza Radiotherapy and Oncology Center, Mashhad, Iran

    Mohammad Amin Kerachian

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  1. Jamshid Motaei
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Correspondence to Mohammad Ahmadvand or Mohammad Amin Kerachian.

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Motaei, J., Yaghmaie, M., Pashaiefar, H. et al. Differential microRNAs expression in acute graft-versus-host disease as potential diagnostic biomarkers. Bone Marrow Transplant 55, 2339–2342 (2020). https://doi.org/10.1038/s41409-020-0949-7

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