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Impact of severe acute kidney injury and chronic kidney disease on allogeneic hematopoietic cell transplant recipients: a retrospective single center analysis

Bone Marrow Transplantation volume 55, pages 1264–1271 (2020)Cite this article

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Abstract

Acute kidney injury (AKI) increases early mortality in allogeneic hematopoietic cell transplant (allo-HCT) recipients and may accelerate chronic kidney disease (CKD) development. We analyzed prospective variables related to AKI and CKD in 422 allo-HCT recipients to establish risk factors of severe acute renal failure and CKD. Renal function and creatinine were periodically assessed from baseline till the last follow-up. Sixty-three patients (14%) developed severe AKI (AKI-3) at 100 days post transplant and 15% at 12 months. Variables associated with AKI-3 were age above 55 years [hazard ratio (HR): 2.4; p = 0.019], total body irradiation (TBI) (HR: 1.8; p = 0.044), high-risk cytomegalovirus reactivation (HR: 1.8; p = 0.041), and methotrexate as GVHD prophylaxis (HR: 2.1; p = 0.024). AKI-3 increased the mortality risk (HR: 2.5, 95% confidence interval: 1.9–3.4). The CKD prevalence in 161 living patients was 10.2% at the last follow-up and in most, CKD developed 1 year post HCT, independent of AKI. The CKD at 1 year post HCT was associated with increased mortality (HR: 3.54; p < 0.001). Interestingly, pretransplant CKD was associated with early mortality (HR: 5.6; p < 0.001). In fact, pre- and posttransplant CKD had independent unfavorable long-term outcomes. These pretransplant factors can potentially be targeted to improve allo-HCT outcomes.

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Author notes

  1. These authors contributed equally: Gonzalo Gutiérrez-García, Jesús Villarreal, Marta Garrote

Authors and Affiliations

  1. Bone Marrow Transplant Unit, Department of Hematology, Hospital Clínic of Barcelona, Barcelona, Spain

    Gonzalo Gutiérrez-García, Marta Garrote, Montserrat Rovira, María Suárez-Lledó, Luis Gerardo Rodríguez-Lobato, Paola Charry, Laura Rosiñol, Pedro Marín, Alexandra Pedraza, María Teresa Solano, Carla Ramos, Noemí de Llobet, Carmen Martínez, Álvaro Urbano-Ispizua & Francesc Fernández-Avilés

  2. University of Barcelona, Barcelona, Spain

    Gonzalo Gutiérrez-García, Jesús Villarreal, Marta Garrote, Montserrat Rovira, Miquel Blasco, María Suárez-Lledó, Luis Gerardo Rodríguez-Lobato, Paola Charry, Laura Rosiñol, Pedro Marín, Alexandra Pedraza, Miquel Lozano, Joan Cid, Carmen Martínez, Esteban Poch, Álvaro Urbano-Ispizua, Francesc Fernández-Avilés, A. Pereira & Luis F. Quintana

  3. Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain

    Gonzalo Gutiérrez-García, Jesús Villarreal, Marta Garrote, Montserrat Rovira, Miquel Blasco, María Suárez-Lledó, Luis Gerardo Rodríguez-Lobato, Paola Charry, Laura Rosiñol, Pedro Marín, Alexandra Pedraza, Miquel Lozano, Joan Cid, Carmen Martínez, Esteban Poch, Álvaro Urbano-Ispizua, Francesc Fernández-Avilés, A. Pereira & Luis F. Quintana

  4. Department of Nephrology, Hospital Clínic of Barcelona, Barcelona, Spain

    Jesús Villarreal, Miquel Blasco, Esteban Poch & Luis F. Quintana

  5. Department of Hemotherapy and Hemostasis, Hospital Clínic of Barcelona, Barcelona, Spain

    Miquel Lozano, Joan Cid & A. Pereira

  6. Barcelona Endothelium Team (BET), Josep Carreras Leukemia Research Institute, Barcelona, Spain

    Enric Carreras

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  1. Gonzalo Gutiérrez-García
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Correspondence to Gonzalo Gutiérrez-García.

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Conflict of interest

GG-G: Honoraria from Takeda and honoraria and grant from Jazz Pharmaceutical. LR: Honoraria from Janssen, Celgene, Amgen, and Takeda. The other authors do not have any conflict of interest to declare.

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Gutiérrez-García, G., Villarreal, J., Garrote, M. et al. Impact of severe acute kidney injury and chronic kidney disease on allogeneic hematopoietic cell transplant recipients: a retrospective single center analysis. Bone Marrow Transplant 55, 1264–1271 (2020). https://doi.org/10.1038/s41409-020-0843-3

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