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History of drug use in allogeneic hematopoietic cell transplant recipients

Bone Marrow Transplantation volume 56, pages 581–585 (2021)Cite this article

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A Correction to this article was published on 21 October 2020

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Abstract

Allogeneic hematopoietic cell transplant (HCT) is a curative therapy for malignant and non-malignant blood diseases. Drug use may be associated with adverse outcomes. We performed a retrospective analysis to assess non-relapse mortality (NRM) and overall survival (OS) in HCT patients with drug use. The medical charts of 232 patients were reviewed. Recipients of matched unrelated donor (MUD) or matched related donor (MRD) transplants were included. Drug use was defined by either metabolic evidence or provider documentation prior to transplant. Transplants were MUD (n = 148) or MRD (n = 84). Median follow-up duration was 15.5 months. There were 35 (15%) patients in the drug use group and 197 (85%) patients in the control group; 49% and 60.4% were in remission at the time of transplant, respectively. In univariate analysis, drug use was associated with a 3-year cumulative incidence of NRM of 43% vs 29% for the control group (p = 0.048), and an HR of 1.75, (95% CI: 1.02–2.99). After controlling for age, sex, disease status, and graft type, drug use was associated with a hazard ratio (HR) of 1.6 (95% CI: 0.95–2.92) for NRM, and an HR 1.2 (95% CI: 0.74–1.94) for OS. Larger cohorts may be needed to further evaluate this association.

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Fig. 1: Cumulative incidence of non-relapse mortality by illicit drug use at 3 years post-transplant.
Fig. 2: Kaplan–Meier estimations of overall survival for patients with a history of drug use compared to patients with no history of drug use.

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Change history

  • 08 October 2020

    The original version of this Article contained an error in the presentation of the author name for Dr. Abou-Ismail. The first name was incorrectly published as Mouhamed instead of Mouhamed Yazan and the family name as Yazan Abou-Ismail instead of Abou-Ismail. This has now been corrected in both the PDF and HTML versions of the Article.

  • 21 October 2020

    A Correction to this paper has been published: https://doi.org/10.1038/s41409-020-01085-w

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Authors and Affiliations

  1. University Hospitals Seidman Cancer Center, Cleveland, OH, USA

    Mouhamed Yazan Abou-Ismail, Gayathri Ravi, Sowjanya Vuyyala, Paolo Caimi, Merle Kolk, Nicole Ferrari, Kirsten Boughan, Brenda Cooper, Molly Gallogly, Folashade Otegbeye, Benjamin Tomlinson, Marcos de Lima & Leland Metheny

  2. Case Western Reserve University, Cleveland, OH, USA

    Mouhamed Yazan Abou-Ismail, Gayathri Ravi, Pingfu Fu, Shufen Cao, Paolo Caimi, Kirsten Boughan, Brenda Cooper, Molly Gallogly, Folashade Otegbeye, Benjamin Tomlinson, Marcos de Lima & Leland Metheny

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Abou-Ismail, M.Y., Ravi, G., Fu, P. et al. History of drug use in allogeneic hematopoietic cell transplant recipients. Bone Marrow Transplant 56, 581–585 (2021). https://doi.org/10.1038/s41409-020-01058-z

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