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Effect of low platelet HLA-C expression on donor-specific antibody depletion following platelet transfusion from a corresponding HLA donor

Bone Marrow Transplantation volume 54, pages 1713–1716 (2019)Cite this article

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HLA antibodies are produced during allogeneic immune responses, such as pregnancy, blood transfusion, and allogeneic transplantation. Donor-specific HLA antibodies (DSA) contribute to graft failure in HLA-mismatched allogeneic hematopoietic stem cell transplantation (HSCT) [1,2,3]. Additionally, the intensity of DSA measured using mean fluorescence intensity (MFI) correlates with graft failure. When we perform HSCT for DSA-positive patients, DSA reduction is warranted.

The Patient with high levels of DSA experienced rapid engraftment with DSA desensitization therapy, including transfusion of platelets expressing DSA-targeted HLA (DSA-PC) in HLA-mismatched transplantation from family members (haploHSCT) [4]. The consensus guidelines for DSA including this method was published from the European Society for Blood and Marrow Transplantation in 2018 [5].

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Authors and Affiliations

  1. Department of Hematology, Nephrology and Rheumatology, Graduate School of Medicine, Akita University, Akita, Japan

    Takaya Yamashita, Fumiko Ito, Takahiro Kobayashi, Miho Nara & Naoto Takahashi

  2. Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

    Kazuhiro Ikegame, Takayuki Inoue & Katsuji Kaida

  3. Division of Blood Transfusion, Akita University Hospital, Akita, Japan

    Naohito Fujishima

  4. Division of Radiology and Radiation Medicine, Graduate School of Medicine, Akita University, Akita, Japan

    Akira Anbai

  5. HLA Foundation Laboratory, Kyoto, Japan

    Hidenori Tanaka

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  1. Takaya Yamashita
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  2. Kazuhiro Ikegame
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Correspondence to Takaya Yamashita.

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Yamashita, T., Ikegame, K., Ito, F. et al. Effect of low platelet HLA-C expression on donor-specific antibody depletion following platelet transfusion from a corresponding HLA donor. Bone Marrow Transplant 54, 1713–1716 (2019). https://doi.org/10.1038/s41409-019-0482-8

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