Abstract
Objectives
This study aimed to evaluate the effect of fractional radiation on the mechanical properties of fluoride-releasing materials.
Materials and methods
High-viscosity glass ionomer cement (F9), resin-modified glass ionomer cement (F2), glass hybrid restoration (EQ), and bioactive composite (AC) were divided into 3 subgroups: 0, 35, and 70 Gy fractional radiation doses. The specimens were subjected to surface roughness, Vickers microhardness, and compressive strength tests. The chemical components and morphology of the tested specimens were observed via energy dispersive spectroscopy and scanning electron microscopy. The data were analyzed using two–way ANOVA with Bonferroni post hoc analysis.
Results
After exposure to fractional radiation, the surface roughness increased in all the groups. F9 had the highest surface roughness, while AC had the lowest surface roughness within the same radiation dose. The Vickers microhardness decreased in F9 and EQ. The AC had the highest compressive strength among all the groups, followed by F2. More cracks and voids were inspected, and no substantial differences in the chemical components were observed.
Conclusions
After fractional radiation, the surface roughness of all fluoride-releasing materials increased, while the Vickers microhardness of F9 and EQ decreased. However, the compressive strength increased only in F2 and AC.
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Introduction
Head and neck cancer is a significant global health challenge. The newly diagnosed cases annually comprise approximately 380,000 in the lip and oral cavity, 133,000 in the nasopharynx, 98,000 in the oropharynx, and 54,000 in the salivary glands [1]. Among the primary treatment modalities for head and neck cancer patients, radiotherapy is commonly employed. Its impact extends beyond the intended target of malignant tumors, affecting adjacent tissues and dental restorative materials. A multitude of complications can arise as a consequence of radiation exposure after head and neck radiotherapy (HNRT) since radiation can damage salivary glands, causing a lack of saliva or xerostomia, which leads to radiation caries [2].
Fluoride-releasing materials such as glass ionomer cement (GIC) have been widely used in restorative dentistry to treat carious lesions for several decades and have been developed to improve their mechanical properties. The development of fluoride-releasing materials has focused mainly on increasing the amount of glass filler and liquid. High viscosity GICs (Fuji IX GP Extra - F9) are categorized as conventional GICs since they are produced by acid-base reactions from powder – liquid mixtures with higher powder/liquid ratios and high molecular weight polyacrylic acid [3, 4]. To improve the properties of conventional GIC, resin monomers which are 2-hydroxyethyl methacrylate (HEMA) and urethane dimethacrylate (UDMA), along with photoinitiators such as camphorquinone have been incorporated into RMGIC (Fuji II LC – F2). RMGIC still retains the acid–base reaction of conventional GIC with the addition of radical polymerization of the methacrylate monomer. Another development of fluoride - releasing materials is the use of a glass hybrid material (Equia Forte - EQ) based on GIC technology. The conventional glass matrix was reinforced with ultrafine and highly reactive glass particles dispersed in a conventional glass ionomer structure and included high molecular weight polyacrylic acid [5]. Subsequently, a new bioactive composite (ACTIVA BioACTIVE–RESTORATIVE – AC) has been introduced into the market. The material contains high molecular weight polyacrylic acid similar to high viscosity GIC and RMGIC with the addition of urethane dimethacrylate monomers and dimethacrylate phosphate. All of these fluoride-releasing materials mentioned above are commonly used for both anterior and posterior direct restorations in HNRT patients due to their ability to prevent caries progression before the initiation of radiotherapy, which is particularly important for maintaining oral health in individuals undergoing treatment for head and neck cancer.
An in vitro study revealed that ionizing radiation directly affected the mechanical properties of fluoride-releasing materials. Although several studies stated that radiation can alter the properties of restorative materials, such as microhardness, surface roughness, and compressive strength [3, 6, 7], some studies have shown no detrimental effects [8,9,10]. The scientific literature presents a degree of controversy in regard to the interaction between ionizing radiation and fluoride-releasing materials. Additionally, there is currently limited or no literature on the impact of radiation on these new fluoride-releasing materials.
Owing to the lack of scientific evidence, this study aimed to evaluate the effect of radiation on the mechanical properties of fluoride-releasing materials, including high viscosity GIC, RMGIC, glass hybrid restoration and bioactive composite. The null hypothesis was that radiation would not alter the mechanical properties of fluoride-releasing materials.
Materials and methods
Ethical review and approval were waived for this study due to the nature of study was the material study. There was no involvement of human subjects and human specimens. Four fluoride-releasing materials were used in this study. Table 1 presents the composition, manufacturer’s instructions, and group codes of tested materials. The specimens in each group were divided into 3 subgroups: nonirradiated (control group) and irradiated with 35 Gy, and 70 Gy (experimental group).
Sample size calculation
The sample size was calculated using G*Power software version 3.1. The parameters were set with a 95% confidence interval, 95% power, and 0.97 effect size. The reference values were taken from a previous study by Brandeburski et al. [11]. The total sample size was calculated as at least seven specimens per group. Therefore, this study was designed to use 10 specimens per group.
Specimen preparation for the surface roughness and microhardness test
The specimens for F9 and EQ were prepared in transparent cylindrical acrylic molds 4 mm in diameter and 2 mm in height. The capsule was mixed according to the manufacturer’s instructions. The capsule was inserted into a capsule applier, dispensed into the molds avoiding air bubble entrapment and covered with microscope coverslips. The specimens were left for the completed set.
The specimens for F2 and AC were prepared in transparent cylindrical acrylic molds 4 mm in diameter and 2 mm in height. The capsule was mixed according to the manufacturer’s instructions. The capsule was inserted into a capsule applier, dispensed into transparent cylindrical acrylic molds avoiding air bubble entrapment and covered with microscope coverslips. Then, the specimen was light cured with a LED light - curing unit (1200 mW/mm2, DemiTM Plus, Kerr, Orange, CA, USA) above the glass plate on both sides for 40 s to ensure complete polymerization of the materials.
All specimens were thoroughly measured with a digital vernier caliper to reassure the dimensions of the specimens, which were subsequently examined with a stereomicroscope at 10X magnification (Stereo Microscope SZ61, Olympus, Japan) to ensure that there were no gaps and voids.
Specimen preparation for compressive strength test
The specimens for F9 and EQ were prepared in cylindrical metal molds 4 mm in diameter and 6 mm in height according to ISO9917-1 [12]. The capsule was mixed according to the manufacturer’s instructions. The capsule was inserted into a capsule applier, dispensed into the molds avoiding air bubble entrapment and covered with microscope coverslips.
The specimens for F2 and AC were prepared in cylindrical metal molds 4 mm in diameter and 6 mm in height according to ISO9917-2 [13]. The capsule was mixed according to the manufacturer’s instructions. The mold was filled with 2 mm increment of fluoride-releasing materials avoiding air bubble entrapment, and light cured for 40 s. Then, the next 2 mm increment was filled, and light cured for 40 s. The glass plate was placed above the final increment before light curing for 40 s. To ensure complete polymerization of the materials, the specimen was removed from the mold, and light-cured on the lateral surface area of the cylinder specimen for 40 s.
All specimens were placed on a sieve tray above deionized water in a plastic container at 37 ˚C with a relative humidity of 100%.
Radiation procedure
After 24 h, the specimens in the experimental group were removed from the container and immersed in deionized water, blotted with paper, and exposed to 35 Gy and 70 Gy fractional-dose radiation according to the radiation dose for patients with low- and high-stage head and neck cancer, using an intensity-modulated irradiator (IMRT, Varian RapidArc, Varian Medical Systems, Palo Alto, CA, USA). In the irradiated 35 Gy group, the specimens were exposed to radiation at a rate of 2 Gy per day for 17 consecutive days, with an additional 1 Gy dose administered on the 18th day. For the 70 Gy irradiation group, the specimens received daily radiation doses of 2 Gy for a total of 35 days. The radiation procedure was performed by a radiation therapist at Chonburi Cancer Hospital, Chonburi, Thailand. To calibrate the radiation dose, the Eclipse program (Eclipse Veterinary Software Ltd., Great Chesterford, England) was used for calculation via a computerized tomography scan (Aquilion LB TSX-201A, Toshiba Corp., Tokyo, Japan). After radiation, the plastic containers were restored at 37 °C with a relative humidity of 100%. The radiation procedure was repeated until the assigned radiation dose was obtained for each group.
Surface roughness and microhardness test
Two lines were perpendicularly marked at the center of the specimen as reference lines shown in Fig. 1. The sites for conducting the surface roughness test were measured at a distance of 500 µm, while the sites for the microhardness test were measured at a distance of 200 µm from the horizontal and vertical lines, respectively.
The microhardness was analyzed using a Vickers microhardness tester (FM810, Future-Tech Corp., Kanagawa, Japan) with a 50 g load and 15 s dwell time. The mean microhardness of each specimen was obtained by calculating four indentations. After that, the surface roughness was assessed using non-contact profilometry with the Infinitefocus SL program (Alicona, Graz, Austria). A surface scan was performed with a 10x magnification lens in the area of 0.4 × 0.4 mm. The average roughness (Ra) from each image was calculated.
Compressive strength test
All specimens were subjected to compressive strength test. The measurements were performed with a universal testing machine (8872, Instron, England) using a 2.5 cm long steel head. The load was applied at the center of the specimen with a 1 mm/min crosshead speed until the specimen fractured. The compressive strength of each specimen was expressed in MPa (N/mm2).
Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS)
Three specimens were prepared using the same procedure as for specimen preparation for surface roughness test. The specimens in the experimental group were irradiated as described above. All specimens from each subgroup were coated with gold/palladium, and examined by SEM (Quanta250, FEI, USA). The SEM images were obtained at a magnification of 5000X. A point analysis was performed at the center of the specimens at 15 kV. The average distribution of the chemical compositions from the specimen in each subgroup was calculated as a relative percentage by weight (wt%). The methodology used in this study is shown in Fig. 2.
Statistical analysis
All statistical procedures were performed using SPSS software (IBM SPSS statistics V29.0, IBM; Armonk, NY, USA). The data were evaluated for a normal distribution using the Shapiro-Wilk test. Two – way ANOVA was used to analyze the factors and their interactions. The microhardness, surface roughness and compressive strength were evaluated with Bonferroni post hoc analysis, for which the p value < 0.05. SEM - EDS analysis results were reported as descriptive statistics.
Results
Two-way ANOVA revealed that type of fluoride-releasing materials and radiation dose significantly impacted the surface roughness, microhardness, and compressive strength, as did the interaction between these two factors, as shown in Table 2. The statistical analysis of the surface roughness, microhardness, and compressive strength is shown in Table 3.
The surface roughness test revealed that F9 exhibited the highest surface roughness, while AC demonstrated the lowest surface roughness when comparing materials exposed to the same radiation dose. Among all groups, the 70 Gy group had a significantly greater surface roughness than the other groups within the same materials (p < 0.001) (Fig. 3).
The Vickers microhardness test also demonstrated that F9 had the highest microhardness, while AC had the significantly lowest microhardness among all groups at each radiation dose (p < 0.001). The microhardness in F9-70 and EQ-70 was significantly lower than those at baseline, but there were no significant differences in F2 and EQ among the radiation doses (Fig. 4).
AC had the highest compressive strength, followed by F2. F2-70 and AC-70 had significantly greater compressive strengths than F2-0 and AC-0, respectively (p < 0.05), in contrast to F9-70 and EQ-70, which showed no significant difference form F9-0 and EQ-0 (p > 0.05) (Fig. 5).
SEM images of each group are shown in Fig. 6. More filler particles were exposed on the material surface at a higher radiation dose. F9-0 and EQ-0 showed no voids while F9-35 and EQ-35 exhibited intermittently scattered cracks and voids. Cracks could be clearly observed in the F9-70 and EQ-70 specimens. Compared with those in the F9 and EQ groups, the void and cracked lines in the F2 and AC groups were less pronounced at the same radiation dose. The chemical elements of the main component of each material are presented in Table 4. All tested materials were mainly composed of fluoride (F), calcium (Ca), aluminum (Al), silicon (Si), carbon (C), and oxygen (O). However, phosphorus (P) was detected only in F9, EQ, and AC, while sodium (Na) was detected only in F9 and EQ.
Discussion
This study aimed to verify the effects of ionizing radiation at 0, 35, and 70 Gy on mechanical properties of fluoride-releasing materials. The result revealed that ionizing radiation promoted changes in surface roughness, Vickers microhardness, and compressive strength. Therefore, the null hypothesis was rejected.
The use of IMRT is the accepted method for treating head and neck patients, and the amount of radiation applied depends on the cancer stage and the goal of treatment, whether curative or palliative [14]. During radiotherapy, head and neck cancer patients typically receive a total radiation dose ranging from 14 to 70 Gy which is usually applied in daily fractions of 1.8 to 2 Gy over seven weeks [15]. Therefore, 35 and 70 Gy fractional radiation were used to simulate radiotherapy in the present study.
In this study, a high viscosity GIC (F9) and glass hybrid material (EQ) are categorized as conventional GICs since they are produced by an acid-base reaction, while RMGIC (F2) retains the acid-base reaction with the addition of radical polymerization of the methacrylate monomer. Bioactive composite (AC) has been introduced by the manufacturer as a resin composite with the ability to induce apatite formation from a physiological solution. However, a study by Tiskaya et.al. revealed that AC could release Ca, P, and F ions but the amount of ions release was relatively low, and apatite formation was not observed. This indicated that the glass components in AC were fluoro-alumino-silicate glasses that could degrade in an acidic environment, resembling the glasses utilized in GIC [16]. Moreover, the resin polymerization reaction of AC is activated by chemopolymerization activators, followed by photopolymerization and acid-base reaction [3]. Therefore, AC is considered to have properties similar to RMGIC.
The surface roughness of fluoride-releasing materials significantly increased after exposure to ionizing radiation, which was in accordance with the findings of Brandeburski et al. The results of the studies showed an increase in surface roughness after fractional radiation at doses of 70.2 Gy [11]. Additional studies had reported that ionizing radiation induced changes in the surface roughness of other fluoride-releasing materials, such as Amalgomer CR (ceramic-reinforced GIC) and Zirconomer (zirconia-reinforced GIC) [17]. This hypothesis suggested that ionizing radiation interacted with the chemical components within the materials, potentially amplifying the radiation effects. However, there has not been a comprehensive explanation of the mechanism for the increase in surface roughness. It is imperative to conduct additional research to explore this phenomenon.
The authors speculated that the increase in surface roughness was probably influenced by water radiolysis, which was the process of water molecules dissociating due to ionizing radiation [18]. Water radiolysis generates various reactive species that potentially interfere with the bonding between the fillers and the matrix, leading to an increase in the surface roughness. The setting reaction of GIC extended several months due to its acid-base reaction. The water diffusion coefficient rate within the GIC materials took 4–6 weeks to reach completion during the maturation process [19]. The water that initiates radiolysis could originate from the material itself and the water storage environment. Due to the higher water content in conventional GIC than in RMGIC, more pronounced surface irregularities were observed in conventional GIC than in RMGIC.
The results of the microhardness test from this study are consistent with those of the research conducted by Amorim et al. who reported a reduction in the Vickers microhardness of conventional GIC after radiation whereas RMGIC value were significantly similar [20]. The hardness of the material was influenced by the number of exposed fillers, the bond stability between the fillers and the matrix, and the surface irregularity. The conventional GIC powder also contained non - silanized fluoroalumiosilicate filler (FASF) and lacked methacrylate monomers. Consequently, less exposure of filler particles could occur if the numerous fillers detach from the material surface, resulting in a decrease in microhardness after radiation [21]. In contrast, RMGIC contains silanized FASF and methacrylate monomers, which increase the stability of the bond between the fillers and the matrix [22].
The decision to conduct a compressive strength test according to ISO9917-1 and ISO9917-2 was made in this study because it is suitable for brittle materials including conventional GIC. The heightened compressive strength in RMGIC could be attributed to the post-cure reactions typical of resin-containing materials. This is possibly because ionizing radiation was absorbed by the inorganic filler particles as well as radiosensitive chemical groups. This radiation then propagates through the resin matrix, leading to excitation and ionization of the matrix and resulting in the generation of reactive species. Therefore, the crosslinking among the polymerized chains of the resin matrix increased. These radicals also gradually converted double bonds over time, resulting in a higher degree of conversion [23] and compressive strength [24]. These results are in agreement with the study by Vaishnavi, who reported that the mechanical properties of radiated resin contained materials further optimized the material properties [25]. An increase in compressive strength was observed only for F2-70 and AC-70. Nevertheless, the compressive strength remained relatively consistent in F9 and EQ due to the absence of a polymerization process in conventional GIC.
The SEM findings were correlated with the surface roughness. Exposure to ionizing radiation results in the dissolution of the material surface, leading to the emergence of subsurface filler particles distributed beneath the surface layer [20]. The surface irregularities of the materials influenced bacterial adhesion and biofilm formation, which could contribute to increased inflammation of the periodontal tissue [11].
EDS analysis revealed no substantial differences in the primary chemical components after radiation. This analysis has limitations in detecting low molar mass elements and was conducted on the surface at a depth of approximately 1 μm. Therefore, this approach did not provide an exact representation of the chemical compositions of the materials [17]. The present study showed that, compared with RMGIC, conventional GIC had a greater percentage of fluoride [26, 27]. The lower fluoride component in RMGIC could be attributed to the fact that the polymerized resin matrix restricted ion exchange with the external environment [26].
Based on this study, RMGIC appeared to be less susceptible to the effect of ionizing radiation on the surface roughness and microhardness with increasing compressive strength. Therefore, RMGIC could be considered a preliminary restorative material before the initiation of radiotherapy.
The coating agent was not applied after specimen preparation in any of the groups since it would be dislodged after clinical use due to the masticatory force and brushing process [28]. Consequently, our study was intentionally designed to assess the performance of fluoride-releasing materials without the influence of additional coatings. The specimens in this study were stored in distilled water since most HNRT patients typically experience hyposalivation to simulate the worst-case scenario. It has been reported that the parotid gland can reduce salivary function at a mean dose exceeding 20–25 Gy after radiation [29]. Moreover, an increased risk of oral candidiasis was reported in HNRT patients due to a reduction in the salivary flow rate [30]. Changes in microbial colonies in the oral cavity may impact the mechanical properties and longevity of restorative materials. Therefore, further research is needed to gather additional information in this regard.
Conclusion
According to the results of this study, it is concluded that the exposure to ionizing radiation negatively affected certain mechanical properties of the fluoride-releasing materials, particularly conventional glass ionomer cement.
Data availability
The data supporting the findings of this study can be obtained from the corresponding author, DN, upon reasonable request.
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Acknowledgements
The authors gratefully acknowledge the staff at Chonburi Cancer Hospital, Chonburi, Thailand for assistance with the irradiation procedure. We appreciate all support from the Dental Material Research and Development Center, Faculty of Dentistry, Chulalongkorn University.
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Pimduean Sivavong (PS): Conceptualization, Writing - Original Draft, Writing - Review & Editing, Visualization. Chanyared Sanprasert (CS): Methodology, Investigation, Writing - Original Draft. Proudfah Leekhaphan (PL): Investigation, Writing - Original Draft. Somsuda Chooboonlarp (SC): Investigation, Writing - Original Draft. Chalermchart Bunsong (CB): Methodology. Chawalid Pianmee (CP): Resources, Data Curation. Potsawat Poolkerd (PP): Resources, Data Curation. Thawanrat Singthong (TS): Formal analysis. Puliwan Gorwong (PG): Formal analysis. Dusit Nantanapiboon (DN): Conceptualization, Writing - Review & Editing, Visualization, Supervision, Project administration, Funding acquisition.
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The authors declare no conflicts of interest. Ethical review and approval were waived for this study due to the nature of study was the material study. There was no involvement of human subjects and human specimens.
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Sivavong, P., Sanprasert, C., Leekhaphan, P. et al. Effect of ionizing radiation on the mechanical properties of current fluoride-releasing materials. BDJ Open 10, 10 (2024). https://doi.org/10.1038/s41405-024-00192-w
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DOI: https://doi.org/10.1038/s41405-024-00192-w