Abstract
Background
Invasive bacterial infections (IBIs) in febrile infants are rare but potentially devastating. We aimed to derive and validate a predictive model for IBI among febrile infants age 7–60 days.
Methods
Data were abstracted retrospectively from electronic records of 37 emergency departments (EDs) for infants with a measured temperature >=100.4 F who underwent an ED evaluation with blood and urine cultures. Models to predict IBI were developed and validated respectively using a random 80/20 dataset split, including 10-fold cross-validation. We used precision recall curves as the classification metric.
Results
Of 4411 eligible infants with a mean age of 37 days, 29% had characteristics that would likely have excluded them from existing risk stratification protocols. There were 196 patients with IBI (4.4%), including 43 (1.0%) with bacterial meningitis. Analytic approaches varied in performance characteristics (precision recall range 0.04–0.29, area under the curve range 0.5–0.84), with the XGBoost model demonstrating the best performance (0.29, 0.84). The five most important variables were serum white blood count, maximum temperature, absolute neutrophil count, absolute band count, and age in days.
Conclusion
A machine learning model (XGBoost) demonstrated the best performance in predicting a rare outcome among febrile infants, including those excluded from existing algorithms.
Impact
-
Several models for the risk stratification of febrile infants have been developed. There is a need for a preferred comprehensive model free from limitations and algorithm exclusions that accurately predicts IBIs.
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This is the first study to derive an all-inclusive predictive model for febrile infants aged 7–60 days in a community ED sample with IBI as a primary outcome.
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This machine learning model demonstrates potential for clinical utility in predicting IBI.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
Research reported in this publication was supported by the Kaiser Permanente Garfield Memorial Fund. We would also like to thank the KPNC Division of Research and the KPSC Care Improvement Research Team for their infrastructure support.
Prior presentation/publication
May 2022 at the Society for Academic Emergency Medicine Annual Meeting in New Orleans, LA.
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DWB conceptualized and designed the study, collected data, drafted the initial manuscript, and reviewed and revised the manuscript. MER, JH, TLG, ALS, AND DGM conceptualized and designed the study, collected data, and critically reviewed and revised the manuscript. DRV, THPN, BRY, PVW, AND MVK, conceptualized and designed the study, and critically reviewed and revised the manuscript. ASR, JYZ, AND SJP assisted in conceptualizing and designing the study, designed the data collection instruments, coordinated data collection, and reviewed and revised the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
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Ballard, D.W., Huang, J., Sharp, A.L. et al. An all-inclusive model for predicting invasive bacterial infection in febrile infants age 7–60 days. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03141-3
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DOI: https://doi.org/10.1038/s41390-024-03141-3