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Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study

Neuropsychopharmacology volume 48, pages 1910–1919 (2023)Cite this article

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Abstract

Bipolar disorder co-occurs with alcohol use disorder at a rate 3–5 times higher than the general population. We recently reported that individuals with bipolar disorder differ in the positive stimulating and anxiolytic effects of alcohol compared with healthy peers. This study used a randomized, placebo-controlled, cross-over, within-subject alcohol administration design to investigate neurobiological mechanisms within ventral prefrontal cortical (vPFC) systems that may underlie altered sensitivity to alcohol in bipolar disorder (NCT04063384). Forty-seven young adults (n = 23 with bipolar disorder, 64% women) completed clinical assessment and two beverage administration sessions (alcohol and placebo, counter-balanced). Participants were dosed to 0.08 g% breath alcohol concentration during the alcohol condition and completed measures of subjective response to alcohol and an emotional processing fMRI task during the ascending limb. Timing during the placebo condition mirrored the alcohol session. Acute alcohol was associated with reduced functional connectivity between the insula – subcallosal cingulate cortex, and increased connectivity between the left nucleus accumbens – ventromedial PFC in bipolar disorder, but with no change in functional connectivity between these regions in healthy peers. Alcohol-related increases in nucleus accumbens – ventromedial PFC functional connectivity was associated with greater positive stimulating effects of alcohol in bipolar disorder and heavier recent alcohol use. Results suggest vPFC brain systems respond differently to acute alcohol during emotional processing in young adults with bipolar disorder compared with healthy peers, and that vPFC system responses relate to the subjective experience of intoxication and recent alcohol use.

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Fig. 1: Beverage Session timeline of experimental procedures.
Fig. 2: Functional connectivity response during alcohol and placebo conditions.
Fig. 3: Alcohol-induced changes in nucleus accumbens (NAcc) – ventromedial prefrontal cortex (vmPFC) functional connectivity are associated with positive stimulating effects of alcohol and recent alcohol use.

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References

  1. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 1990;264:2511–8.

    CAS  PubMed  Google Scholar 

  2. Goldberg JF. Bipolar disorder with comorbid substance abuse: diagnosis, prognosis, and treatment. J Psychiatr Pr. 2001;7:109–22.

    CAS  Google Scholar 

  3. Fleck DE, Arndt S, DelBello MP, Strakowski SM. Concurrent tracking of alcohol use and bipolar disorder symptoms. Bipolar Disord. 2006;8:338–44.

    PubMed  Google Scholar 

  4. Strakowski SM, DelBello MP, Fleck DE, Adler CM, Anthenelli RM, Keck PE Jr, et al. Effects of Co-occurring Alcohol Abuse on the Course of Bipolar Disorder Following a First Hospitalization for Mania. Arch Gen Psychiatry. 2005;62:851–858.

    PubMed  Google Scholar 

  5. Ray LA, Mackillop J, Monti PM. Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. Subst Use Misuse. 2010;45:1742–65.

    PubMed  PubMed Central  Google Scholar 

  6. Quinn PD, Fromme K. Subjective response to alcohol challenge: a quantitative review. Alcohol Clin Exp Res. 2011;35:1759–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. King A, Vena A, Hasin DS, deWit H, O'Connor SJ, Cao D. Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder. Am J Psychiatry. 2021;178:560–571.

    PubMed  PubMed Central  Google Scholar 

  8. King AC, McNamara PJ, Hasin DS, Cao D. Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. Biol Psychiatry. 2014;75:798–806.

    PubMed  Google Scholar 

  9. King AC, de Wit H, McNamara PJ, Cao D. Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry. 2011;68:389–99.

    PubMed  PubMed Central  Google Scholar 

  10. Yip SW, Doherty J, Wakeley J, Saunders K, Tzagarakis C, de Wit H, et al. Reduced subjective response to acute ethanol administration among young men with a broad bipolar phenotype. Neuropsychopharmacology. 2012;37:1808–15.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Lippard ETC, Kirsch DE, Kosted R, Le V, Almeida J, Fromme K, et al. Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study. Psychopharmacol (Berl). 2023;240:739–753.

    CAS  Google Scholar 

  12. Tretyak V, Kirsch DE, Radpour S, Weber WA, Fromme K, Strakowski SM, et al. Subjective Response to Alcohol: Associated Alcohol Use and Orbitofrontal Gray Matter Volume in Bipolar Disorder. J Affect Disord. 2020;279:671–679.

    PubMed  PubMed Central  Google Scholar 

  13. Bjork JM, Gilman JM. The effects of acute alcohol administration on the human brain: insights from neuroimaging. Neuropharmacology. 2014;84:101–10.

    CAS  PubMed  Google Scholar 

  14. Gilman JM, Ramchandani VA, Davis MB, Bjork JM, Hommer DW. Why we like to drink: a functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol. J Neurosci. 2008;28:4583–91.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Padula CB, Simmons AN, Matthews SC, Robinson SK, Tapert SF, Schuckit MA, et al. Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study. Alcohol Alcohol. 2011;46:547–52.

    PubMed  PubMed Central  Google Scholar 

  16. Gorka SM, Fitzgerald DA, King AC, Phan KL. Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study. Psychopharmacol (Berl). 2013;229:141–54.

    CAS  Google Scholar 

  17. Han J, Keedy S, Murray CH, Foxley S, de Wit H. Acute effects of alcohol on resting-state functional connectivity in healthy young men. Addict Behav. 2021;115:106786.

    PubMed  Google Scholar 

  18. Boissoneault J, Stennett B, Robinson ME. Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures. Drug Alcohol Depend. 2020;207:107811.

    PubMed  Google Scholar 

  19. Gorka SM, Phan KL, Childs E. Acute calming effects of alcohol are associated with disruption of the salience network. Addict Biol. 2018;23:921–930.

    PubMed  Google Scholar 

  20. Gilman JM, Ramchandani VA, Crouss T, Hommer DW. Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns. Neuropsychopharmacology. 2012;37:467–77.

    CAS  PubMed  Google Scholar 

  21. Paulus MP, Schuckit MA, Tapert SF, Tolentino NJ, Matthews SC, Smith TL, et al. High versus low level of response to alcohol: evidence of differential reactivity to emotional stimuli. Biol Psychiatry. 2012;72:848–55.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Weafer J, Ross TJ, O'Connor S, Stein EA, de Wit H, Childs E. Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. Neuropsychopharmacology. 2018;43:2532–2538.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. McKenna BS, Anthenelli RM, Smith TL, Schuckit MA. Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli. Alcohol Clin Exp Res. 2022;46:66–76.

    PubMed  PubMed Central  Google Scholar 

  24. Strakowski SM, Adler CM, Almeida J, Altshuler LL, Blumberg HP, Chang KD, et al. The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord. 2012;14:313–25.

    PubMed  Google Scholar 

  25. Lippard ET, Mazure CM, Johnston JA, Spencer L, Weathers J, Pittman B, et al. Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents. J Neurosci Res. 2017;95:777–791.

    PubMed  Google Scholar 

  26. Baker TB, Piper ME, McCarthy DE, Majeskie MR, Fiore MC. Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychol Rev. 2004;111:33–51.

    PubMed  Google Scholar 

  27. First MB, Williams JBW, Karg RS, Spitzer RL. Structured Clinical Interview for DSM-5—Research Version (SCID-5 for DSM-5, Research Version; SCID-5-RV). 2015.

  28. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32:50–5.

    CAS  PubMed  Google Scholar 

  29. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;25:56–61.

    Google Scholar 

  30. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429–35.

    CAS  PubMed  Google Scholar 

  31. Andreasen NC, Endicott J, Spitzer RL, Winokur G. The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry. 1977;34:1229–35.

    CAS  PubMed  Google Scholar 

  32. Corporation, P. Wechsler Abbreviated Scale of Intelligence Manual. 1999, San Antonio: TXHarcourt Brace and Company.

  33. Curtin JJ, Fairchild BA. Alcohol and cognitive control: implications for regulation of behavior during response conflict. J Abnorm Psychol. 2003;112:424–36.

    PubMed  Google Scholar 

  34. Watson PE. Total body water and blood alcohol levels: Updating the fundamentals. Hum Metab Alcohol. 1989;1:41–58.

    Google Scholar 

  35. Patrica E, Watson IanD, Watson RDB. Prediction of Blood Alcohol Concentration in Human Subjects. J Stud Alcohol. 1981;42:547–556.

    Google Scholar 

  36. Quinn PD, Fromme K. Individual differences in subjective alcohol responses and alcohol-related disinhibition. Exp Clin Psychopharmacol. 2016;24:90–9.

    PubMed  PubMed Central  Google Scholar 

  37. Cofresí RU, Bartholow BD, Fromme K. Female drinkers are more sensitive than male drinkers to alcohol-induced heart rate increase. Exp Clin Psychopharmacol. 2020;28:540–552.

    PubMed  Google Scholar 

  38. Corbin WR, Hartman JD, Bruening AB, Fromme K. Contextual influences on subjective alcohol response. Exp Clin Psychopharmacol. 2021;29:48–58.

    PubMed  Google Scholar 

  39. Morean ME, de Wit H, King AC, Sofuoglu M, Rueger SY, O'Malley SS. The drug effects questionnaire: psychometric support across three drug types. Psychopharmacol (Berl). 2013;227:177–92.

    CAS  Google Scholar 

  40. Yamasaki H, LaBar KS, McCarthy G. Dissociable prefrontal brain systems for attention and emotion. Proc Natl Acad Sci USA. 2002;99:11447–51.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Strakowski SM, Eliassen JC, Lamy M, Cerullo MA, Allendorfer JB, Madore M, et al. Functional magnetic resonance imaging brain activation in bipolar mania: evidence for disruption of the ventrolateral prefrontal-amygdala emotional pathway. Biol Psychiatry. 2011;69:381–8.

    PubMed  Google Scholar 

  42. Strakowski SM, Fleck DE, Welge J, Eliassen JC, Norris M, Durling M, et al. fMRI brain activation changes following treatment of a first bipolar manic episode. Bipolar Disord. 2016;18:490–501.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Lippard ETC, Weber W, Welge J, Adler CM, Fleck DE, Almeida J, et al. Variation in Rostral Anterior Cingulate Functional Connectivity with Amygdala and Caudate during First-Manic Episode Distinguish Bipolar Young Adults who do not Remit Following Treatment. Bipolar Disord. 2021;23:500–8.

    PubMed  Google Scholar 

  44. Sobell LC, and Sobell MB. Timeline follow-back: A technique for assessing self-reported alcohol consumption, in Measuring alcohol consumption: Psychosocial and biochemical methods. 1992, Humana Press: Totowa, NJ, US. p. 41–72.

  45. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51:768–74.

    CAS  PubMed  Google Scholar 

  46. Whitfield-Gabrieli S, Nieto-Castanon A. Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks. Brain Connectivity. 2012;2:125–141.

    PubMed  Google Scholar 

  47. Poldrack RA, Mumford JA, Nichols TE. Handbook of Functional MRI Data Analysis, Handbook of Functional MRI Data Analysis. 2011, Cambridge: Cambridge University Press.

  48. Behzadi Y, Restom K, Liau J, Liu TT. A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage. 2007;37:90–101.

    PubMed  Google Scholar 

  49. Cumming, G. The New Statistics – Effect Sizes, Confidence Intervals, and Meta-Analysis. 2012.

  50. Morris SB. Estimating effect sizes from pretest-posttest-control group designs. Organ Res Methods. 2008;11:364–386.

    Google Scholar 

  51. Lenhard A, Lenhard W. Calculation of effect sizes. 2015.

  52. Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review. Bipolar Disord. 2012;14:326–39.

    PubMed  Google Scholar 

  53. Strakowski, S. The Bipolar Brain: Integrating Neuroimaging and Genetics, The bipolar brain: integrating neuroimaging and genetics. 2022: Oxford University Press.

  54. Margulies DS, Kelly AM, Uddin LQ, Biswal BB, Castellanos FX, Milham MP. Mapping the functional connectivity of anterior cingulate cortex. Neuroimage. 2007;37:579–88.

    PubMed  Google Scholar 

  55. Johnson SL, Edge MD, Holmes MK, Carver CS. The behavioral activation system and mania. Annu Rev Clin Psychol. 2012;8:243–67.

    PubMed  Google Scholar 

  56. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217–38.

    PubMed  Google Scholar 

  57. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357–381.

    CAS  PubMed  Google Scholar 

  58. Pizzagalli DA, Goetz E, Ostacher M, Iosifescu DV, Perlis RH. Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task. Biol Psychiatry. 2008;64:162–8.

    PubMed  PubMed Central  Google Scholar 

  59. Yip SW, Worhunsky PD, Rogers RD, Goodwin GM. Hypoactivation of the ventral and dorsal striatum during reward and loss anticipation in antipsychotic and mood stabilizer-naive bipolar disorder. Neuropsychopharmacology. 2015;40:658–66.

    CAS  PubMed  Google Scholar 

  60. Schreiter S, Spengler S, Willert A, Mohnke S, Herold D, Erk S, et al. Neural alterations of fronto-striatal circuitry during reward anticipation in euthymic bipolar disorder. Psychol Med. 2016;46:3187–3198.

    CAS  PubMed  Google Scholar 

  61. Johnson SL, Mehta H, Ketter TA, Gotlib IH, Knutson B. Neural responses to monetary incentives in bipolar disorder. NeuroImage: Clin. 2019;24:102018.

    PubMed  Google Scholar 

  62. Liu R, Wang Y, Chen X, Zhang Z, Xiao L, Zhou Y. Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder. Neuroimage Clin. 2021;30:102599.

    PubMed  PubMed Central  Google Scholar 

  63. Satterthwaite TD, Kable JW, Vandekar L, Katchmar N, Bassett DS, Baldassano CF, et al. Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression. Neuropsychopharmacology. 2015;40:2258–68.

    PubMed  PubMed Central  Google Scholar 

  64. Kroemer NB, Opel N, Teckentrup V, Li M, Grotegerd D, Meinert S, et al. Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression. JAMA Psychiatry. 2022;79:993–1003.

    PubMed  PubMed Central  Google Scholar 

  65. Stanton CH, Holmes AJ, Chang S, Joormann J. From Stress to Anhedonia: Molecular Processes through Functional Circuits. Trends Neurosci. 2019;42:23–42.

    CAS  PubMed  Google Scholar 

  66. Dimick MK, Hird MA, Fiksenbaum LM, Mitchell R, Goldstein BI. Severe anhedonia among adolescents with bipolar disorder is common and associated with increased psychiatric symptom burden. J Psychiatr Res. 2021;134:200–7.

    PubMed  Google Scholar 

  67. Heller AS, Johnstone T, Light SN, Peterson MJ, Kolden GG, Kalin NH, et al. Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment. Am J Psychiatry. 2013;170:197–206.

    PubMed  PubMed Central  Google Scholar 

  68. Lally N, Nugent AC, Luckenbaugh DA, Ameli R, Roiser JP, Zarate CA. Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression. Transl Psychiatry. 2014;4:e469.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Nugent AC, Diazgranados N, Carlson PJ, Ibrahim L, Luckenbaugh DA, Brutsche N, et al. Neural correlates of rapid antidepressant response to ketamine in bipolar disorder. Bipolar Disord. 2014;16:119–28.

    CAS  PubMed  Google Scholar 

  70. Kirsch DE, Le V, Kosted R, Fromme K, Lippard E. Neural Underpinnings of Expecting Alcohol: Placebo Alcohol Administration Alters Nucleus Accumbens Resting State Functional Connectivity. Behavioural Brain Res. 2022;437:114148.

    Google Scholar 

  71. Prisciandaro JJ, Brown DG, Brady KT, Tolliver BK. Comorbid anxiety disorders and baseline medication regimens predict clinical outcomes in individuals with co-occurring bipolar disorder and alcohol dependence: Results of a randomized controlled trial. Psychiatry Res. 2011;188:361–5.

    PubMed  PubMed Central  Google Scholar 

  72. Koob GF, Volkow ND. Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry. 2016;3:760–73.

    PubMed  PubMed Central  Google Scholar 

  73. Schuckit MA, Smith TL, Kalmijn J, Danko GP. A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. Alcohol Clin Exp Res. 2005;29:1921–7.

    PubMed  Google Scholar 

  74. Carmiol N, Peralta JM, Almasy L, Contreras J, Pacheco A, Escamilla MA, et al. Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. Eur Psychiatry. 2014;29:282–7.

    CAS  PubMed  Google Scholar 

  75. Rosa AR, Reinares M, Franco C, Comes M, Torrent C, Sánchez-Moreno J, et al. Clinical predictors of functional outcome of bipolar patients in remission. Bipolar Disord. 2009;11:401–9.

    PubMed  Google Scholar 

  76. MacQueen GM, Marriott M, Begin H, Robb J, Joffe RT, Young LT. Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder. Bipolar Disord. 2003;5:349–55.

    PubMed  Google Scholar 

  77. Frye MA, Yatham LN, Calabrese JR, Bowden CL, Ketter TA, Suppes T, et al. Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials. J Clin Psychiatry. 2006;67:1721–8.

    CAS  PubMed  Google Scholar 

  78. Bonnín CM, Martínez-Arán A, Torrent C, Pacchiarotti I, Rosa AR, Franco C, et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study. J Affect Disord. 2010;121:156–60.

    PubMed  Google Scholar 

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Acknowledgements

We thank our participants for volunteering their time and supporting our research. We would like to thank our clinical team for reviewing safety of participant medications for participation in alcohol administration procedures. This clinical trial is registered at ClinicalTrials.gov under the title “Acute Alcohol Response in Bipolar Disorder: a fMRI Study” (Identifier: NCT04063384) and can be found at: https://clinicaltrials.gov/ct2/show/NCT04063384.

Funding

This study was funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) K01AA027573. Authors were supported by research grants from the NIAAA: F31AA029005 (DEK); K01AA027573 (RK, VL, ETCL); R21AA027884 (RK, VL, JRCA, KF, SMS, ETCL); R01AA020637 (KF); and the Jones/Bruce Fellowship from the Waggoner Center for Alcohol and Addiction Research (DEK).

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA

    Dylan E. Kirsch, Raquel Kosted, Vanessa Le, Jorge R. C. Almeida, Stephen M. Strakowski & Elizabeth T. C. Lippard

  2. Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA

    Dylan E. Kirsch, Stephen M. Strakowski & Elizabeth T. C. Lippard

  3. Institute for Neuroscience, University of Texas, Austin, TX, USA

    Dylan E. Kirsch, Kim Fromme, Stephen M. Strakowski & Elizabeth T. C. Lippard

  4. Department of Psychology, University of Texas, Austin, TX, USA

    Kim Fromme, Stephen M. Strakowski & Elizabeth T. C. Lippard

  5. Institute of Early Life Adversity Research, University of Texas, Austin, TX, USA

    Elizabeth T. C. Lippard

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Contributions

All authors had full access to the data and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept, design, and acquisition of funding: ETCL. Acquisition of data: ETCL, DEK, VL, RK. Statistical analyses and interpretation of data: ETCL, DEK. Drafting of manuscript: ETCL, DEK. Critical revision of the manuscript: ETCL, DEK, RK, VL, JRCA, SMS, KF. Administrative, technical, and material support: ETCL, DEK, RK, VL, JRCA, KF, SMS. Study supervision: ETCL.

Corresponding authors

Correspondence to Dylan E. Kirsch or Elizabeth T. C. Lippard.

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Competing interests

We do not believe any of these relationships could influence the reported results, but we report them for transparency. SMS serves as DSMB chair for Sunovion and served recently on a DMC for Otsuka. He is also a contributor to Medscape. ETCL, JRCA, and SMS received funding for a Janssen-sponsored study through University of Texas at Austin. All other authors report no conflicts of interest.

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Kirsch, D.E., Kosted, R., Le, V. et al. Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study. Neuropsychopharmacol. 48, 1910–1919 (2023). https://doi.org/10.1038/s41386-023-01657-6

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