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Compulsion and substance use disorder: potential importance of boundary conditions

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References

  1. Deroche-Gamonet V, Belin D, Piazza PV. Evidence for addiction-like behavior in the rat. Science. 2004;305:1014–7.

    Article  CAS  PubMed  Google Scholar 

  2. Pascoli V, Hiver A, Li Y, Harada M, Esmaeili V, Lüscher C. Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice. Neuropsychopharmacology. 2022. https://doi.org/10.1038/s41386-022-01429-8.

  3. Nebe S, Kroemer NB, Schad DJ, Bernhardt N, Sebold M, Muller DK, et al. No association of goal-directed and habitual control with alcohol consumption in young adults. Addict Biol. 2018;23:379–93.

    Article  PubMed  Google Scholar 

  4. Hogarth L. Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory. Neuropsychopharmacology. 2020;45:720–35.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Heyman GM. How individuals make choices explains addiction’s distinctive, non-eliminable features. Behav Brain Res. 2021;15:397.

    Google Scholar 

Download references

Funding

Authors are supported by DA046526 and DA049130 (to CGR), and DA045023 and DA047368 (to JSB).

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CDG wrote the initial draft of the commentary, and JSB contributed additional text. Both CDG and JSB edited the manuscript and approved the final version.

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Correspondence to Cassandra D. Gipson.

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Gipson, C.D., Beckmann, J.S. Compulsion and substance use disorder: potential importance of boundary conditions. Neuropsychopharmacol. (2022). https://doi.org/10.1038/s41386-022-01462-7

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