Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Shaping long-range functional connectivity through prefrontal interneuron plasticity

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Synaptic plasticity between mPFC interneurons and their long-range afferents is positioned to exert dynamic control of cognition-supporting functional connectivity.

References

  1. Kupferschmidt DA, Gordon JA. The dynamics of disordered dialogue: Prefrontal, hippocampal and thalamic miscommunication underlying working memory deficits in schizophrenia. Brain Neurosci Adv. 2018;2:2398212818771821.

    Article  Google Scholar 

  2. Abbas AI, Sundiang MJM, Henoch B, Morton MP, Bolkan SS, Park AJ, et al. Somatostatin interneurons facilitate hippocampal-prefrontal synchrony and prefrontal spatial encoding. Neuron. 2018;100:926–39.

    CAS  Article  Google Scholar 

  3. Lee AT, Cunniff MM, See JZ, Wilke SA, Luongo FJ, Ellwood IT, et al. VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks. Neuron. 2019;102:1223–34.

    CAS  Article  Google Scholar 

  4. Sánchez-Bellot C, AlSubaie R, Mishchanchuk K, Wee RWS, MacAskill AF. Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour. Nat Commun. 2022;13:339.

    Article  Google Scholar 

  5. Tejeda HA, Wang H, Flores RJ, Yarur HE. Dynorphin/kappa-opioid receptor system modulation of cortical circuitry. Handb Exp Pharm. 2022;271:223–53.

    Article  Google Scholar 

  6. Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, et al. Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons. Neuron. 2021;110:1068–83.e5.

    Article  Google Scholar 

Download references

Funding

Support for this work is provided by the NINDS Intramural Research Program (ZIA NS003168-04).

Author information

Authors and Affiliations

Authors

Contributions

JAG and DAK conducted a literature review, planned and edited the manuscript. DAK wrote the first draft of the manuscript.

Corresponding author

Correspondence to David A. Kupferschmidt.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kupferschmidt, D.A., Gordon, J.A. Shaping long-range functional connectivity through prefrontal interneuron plasticity. Neuropsychopharmacol. (2022). https://doi.org/10.1038/s41386-022-01395-1

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41386-022-01395-1

Search

Quick links