Relapse to drug use during abstinence is a core feature of addiction. Since the 1980s, this clinical scenario has been studied using animal models where relapse is assessed after experimenter-imposed cessation of drug self-administration by either extinction of the drug-reinforced responding or homecage forced abstinence . However, despite strides toward understanding neuronal mechanisms of relapse in these models, treatment options remain largely unchanged. One potential reason for this state-of-affairs is that animal models of addiction rarely incorporate voluntary aspects of human abstinence, which often occurs due to the availability of alternative nondrug rewards (e.g., employment and supportive social environment). This is exemplified in contingency management where nondrug rewards (monetary vouchers), given in exchange for being drug-free, can maintain abstinence for many months. However, when contingency management discontinues, most drug users relapse.
Based on these considerations, we introduced a contingency management-based relapse model, where we achieve long-lasting voluntary abstinence prior to the relapse tests by giving rats mutually exclusive choices between a drug and palatable food . In the initial study, we trained male rats to self-administer the food and methamphetamine in established addiction models—escalation and DSM-IV-based—and found that rats will voluntarily abstain from drug self-administration for at least 3 weeks and then show incubation of methamphetamine craving (time-dependent increases in drug seeking during abstinence) . Subsequently, we demonstrated the generality of food-choice voluntary abstinence to female rats and to heroin, and that surprisingly voluntary abstinence prevents incubation of heroin craving . In mechanistic studies, we found a role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence , and a role of glutamatergic projections from the anterior insular cortex to central amygdala in relapse after voluntary abstinence .
However, the use of palatable food as the nondrug reward may limit the model’s clinical translation. This is because for most humans, the rewards that compete with drugs are primarily social (family and employment). Based on this consideration, we recently introduced a newer voluntary abstinence model that involves choices between a drug and operant access to social interaction  (Fig. 1). We found that rats trained in established addiction models—escalation, DSM-IV-based, and intermittent access—will voluntarily abstain when given mutually exclusive choices between methamphetamine or heroin versus social interaction. This effect was independent of their ‘addiction score’, persisted through 4 weeks of forced abstinence, and could only be reversed by delay or punishment of the social reward. We also found that social-choice-induced voluntary abstinence prevents the emergence of incubation of methamphetamine craving, even 1 month after cessation of the social choice. This protective effect was associated with activation (assessed by the activity marker Fos) of inhibitory central amygdala PKCδ-expressing neurons and decreased neuronal activity in the anterior insular cortex .
In conclusion, we introduced two novel models of choice-based voluntary abstinence and demonstrated the profound protective effects of positive social interaction on drug addiction and relapse in rat models. Our findings support wider implementation of social-based behavioral treatments, which include not only the established community reinforcement approach, but also social-based psychotherapies and family-based social support systems to provide social support before and during drug-seeking episodes.
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Caprioli D, Venniro M, Zeric T, Li X, Adhikary S, Madangopal R, et al. Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biol Psychiatry. 2015;78:463–73.
Venniro M, Zhang M, Shaham Y, Caprioli D. Incubation of methamphetamine but not heroin craving after voluntary abstinence in male and female rats. Neuropsychopharmacology. 2017;42:1126–35.
Caprioli D, Venniro M, Zhang M, Bossert JM, Warren BL, Hope BT, Shaham Y. Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence. J Neurosci. 2017;37:1014–27.
Venniro M, Caprioli D, Zhang M, Whitaker LR, Zhang S, Warren BL, et al. The anterior insular cortex-->central amygdala glutamatergic pathway is critical to relapse after contingency management. Neuron. 2017;96:414–27 e418.
Venniro M, Zhang M, Caprioli D, Hoots JK, Golden SA, Heins C, et al. Volitional social interaction prevents drug addiction in rat models. Nature Neuroscience. 2018 (In press).
The research was supported by the Intramural Research Program of NIDA (YS), NARSAD Distinguished Investigator Grant Award (YS), and a fellowship from the NIH Center on Compulsive Behaviors (MV).
The authors declare no competing interests
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Venniro, M., Caprioli, D. & Shaham, Y. Novel models of drug relapse and craving after voluntary abstinence. Neuropsychopharmacol 44, 234–235 (2019). https://doi.org/10.1038/s41386-018-0196-4
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