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Parental smartphone use and children’s mental outcomes: a neuroscience perspective

Neuropsychopharmacologyvolume 44pages239240 (2019) | Download Citation

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  1. 1.

    Pew Research Center, Mobile Technology Fact Sheet. Accessed 3 July 2018.

  2. 2.

    Millennials are Top Smartphone users; Nielsen Newswire Reports, Nielson Company LLC. Accessed 3 July 2018.

  3. 3.

    Wiedemann P, Schütz H. Children’s health and RF EMF exposure. Views from a risk assessment and risk communication perspective. Wien Med Wochenschr. 2011;161:226–32.

  4. 4.

    Sudan M, Kheifets L, Arah OA, Olsen J. Cell phone exposures and hearing loss in children in the Danish national birth cohort. Paediatr Perinat Epidemiol. 2013;27:247–57.

  5. 5.

    Redish AD, Gordon JA. Computational psychiatry: new perspectives on mental illness. In: Lupp J editors. Strungmann forum reports, vol. 20. Cambridge, MA: MIT Press; 2016.

  6. 6.

    Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010;68:314–9.

  7. 7.

    Espinosa JS, Stryker MP. Development and plasticity of the primary visual cortex. Neuron. 2012;75:230–49.

  8. 8.

    Sevelinges Y, Sullivan RM, Messaoudi B, Mouly AM. Neonatal odor-shock conditioning alters the neural network involved in odor fear learning at adulthood. Learn Mem. 2008;15:649–56.

  9. 9.

    Sheridan MA, McLaughlin KA. Dimensions of early experience and neural development: deprivation and threat. Trends Cogn Sci. 2014;18:580–5.

  10. 10.

    Weaver IC, Cervoni N, Champagne FA, D’Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7:847–54.

  11. 11.

    Baram TZ, Davis EP, Obenaus A, Sandman CA, Small SL, Solodkin A, Stern H. Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry. 2012;169:907–15.

  12. 12.

    Davis EP, Stout SA, Molet J, Vegetabile B, Glynn LM, Sandman CA, Heins K, Stern H, Baram TZ. Exposure to unpredictable maternal sensory signals influences cognitive development across species. PNAS . 2017;114:10390–5.

  13. 13.

    Molet J, Heins K, Zhuo X, Mei YT, Regev L, Baram TZ, Stern H. Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome. Transl Psychiatry. 2016;6:e702.

  14. 14.

    Glynn LM, Howland MA, Sandman CA, Davis EP, Phelan M, Baram TZ, Stern HS. Prenatal maternal mood patterns predict child temperament and adolescent mental health. J Affect Disord. 2018;228:83–90.

  15. 15.

    Heun-Johnson H, Levitt P. Early-life stress paradigm transiently alters maternal behavior, Dam-Pup interactions, and offspring vocalizations in mice. Front Behav Neurosci. 2016;10:142.

  16. 16.

    Bath KG, Manzano-Nieves G, Goodwill H. Early life stress accelerates behavioral and neural maturation of the hippocampus in male mice. Horm Behav. 2016;82:64–71.

  17. 17.

    Liao XM, Yang XD, Jia J, Li JT, Xie XM, Su YA, Schmidt MV, Si TM, Wang XD. Blockade of corticotropin-releasing hormone receptor 1 attenuates early-life stress-induced synaptic abnormalities in the neonatal hippocampus. Hippocampus. 2014;24:528–40.

  18. 18.

    Derks NA, Krugers HJ, Hoogenraad CC, Joëls M, Sarabdjitsingh RA. Effects of early life stress on synaptic plasticity in the developing hippocampus of male and female rats. PLoS ONE. 2016;11:e0164551

  19. 19.

    Knop J, Joëls M, van der Veen R. The added value of rodent models in studying parental influence on offspring development: opportunities, limitations and future perspectives. Curr Opin Psychol. 2017;15:174–81.

  20. 20.

    Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram TZ. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress. 2017;20:421–48.

  21. 21.

    Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ. NRSF-dependent epigenetic mechanisms in programming stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry. 2018;23:648–57.

  22. 22.

    Gunn BG, Cunningham L, Cooper MA, Corteen NL, Seifi M, Swinny JD, Lambert JJ, Belelli D. Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. J Neurosci. 2013;33:19534–54.

  23. 23.

    Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram TZ. Anhedonia following early-life adversity involves aberrant interaction of reward and anxiety circuits and is reversed by partial silencing of amygdala corticotropin-releasing hormone gene. Biol Psychiatry. 2018;83:137–47.

  24. 24.

    Nelson CA 3rd, Zeanah CH, Fox NA, Marshall PJ, Smyke AT, Guthrie D. Cognitive recovery in socially deprived young children: the Bucharest Early Intervention Project. Science. 2007;318:1937–40.

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The authors’ research has been supported by NIH grants MH73136, NS28912, and MH096889 and by the Hewitt Foundation for Biomedical Research.

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  1. Department of Anatomy/Neurobiology, University of California-Irvine, Irvine, CA, 92697, USA

    • Tallie Z. Baram
    •  & Jessica L. Bolton
  2. Department of Pediatrics, University of California-Irvine, Irvine, CA, 92697, USA

    • Tallie Z. Baram
    •  & Jessica L. Bolton
  3. Department of Neurology, University of California-Irvine, Irvine, CA, 92697, USA

    • Tallie Z. Baram


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The authors declare no competing interests.

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Correspondence to Tallie Z. Baram.

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