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Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice

Molecular Psychiatry (2024)Cite this article

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Abstract

Post-traumatic stress disorder (PTSD) is a hypermnesic condition that develops in a subset of individuals following exposure to severe trauma. PTSD symptoms are debilitating, and include increased anxiety, abnormal threat generalization, and impaired extinction. In developing treatment strategies for PTSD, preclinical studies in rodents have largely focused on interventions that target post-encoding memory processes such as reconsolidation and extinction. Instead, here we focus on forgetting, another post-encoding process that regulates memory expression. Using a double trauma murine model for PTSD, we asked whether promoting neurogenesis-mediated forgetting can weaken trauma memories and associated PTSD-relevant behavioral phenotypes. In the double trauma paradigm, consecutive aversive experiences lead to a constellation of behavioral phenotypes associated with PTSD including increases in anxiety-like behavior, abnormal threat generalization, and deficient extinction. We found that post-training interventions that elevate hippocampal neurogenesis weakened the original trauma memory and decreased these PTSD-relevant phenotypes. These effects were observed using multiple methods to manipulate hippocampal neurogenesis, including interventions restricted to neural progenitor cells that selectively promoted integration of adult-generated granule cells into hippocampal circuits. The same interventions also weakened cocaine place preference memories, suggesting that promoting hippocampal neurogenesis may represent a broadly useful approach in hypermnesic conditions such as PTSD and substance abuse disorders.

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Fig. 1: Development of a double trauma model for PTSD in mice.
Fig. 2: PTSD-like symptoms persist at remote delays.
Fig. 3: Exercise attenuates PTSD-like phenotypes.
Fig. 4: Hyper-integration of adult-generated granule cells weakens PTSD-like behaviors.
Fig. 5: Post-training increases in hippocampal neurogenesis weakens conditioned place preference for cocaine.

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Data availability

The data that were used to support the findings of this study are available from the corresponding author upon request.

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Acknowledgements

This work was supported by a CIHR project grant (PJT-180530) to PWF, and Brain Canada platform, and NIMH grants (RO1MH119421) to SAJ and PWF Additionally we acknowledge generous support from the Brenneman family and the SickKids Foundation. RF was supported by JSPS KAKENHI Grant Number 14J05605, The Kyoto University Foundation, Astellas Foundation for Research on Metabolic Disorders, and SENSHIN Medical Research Foundation. AIR was supported by an NSERC CGS-D award and an NIH 1 F31 MH120920-01 award. We thank Ms. Daisy Lin, Ms. Toni DeCristofaro, and Ms. Mika Yamamoto for technical assistance.

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Authors and Affiliations

  1. Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada

    Risako Fujikawa, Adam I. Ramsaran, Axel Guskjolen, Juan de la Parra, Yi Zou, Andrew J. Mocle, Sheena A. Josselyn & Paul W. Frankland

  2. Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan

    Risako Fujikawa

  3. Department of Psychology, University of Toronto, Toronto, ON, M5S 3G3, Canada

    Adam I. Ramsaran, Sheena A. Josselyn & Paul W. Frankland

  4. Department of Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada

    Axel Guskjolen, Andrew J. Mocle, Sheena A. Josselyn & Paul W. Frankland

  5. Institute of Medical Sciences, University of Toronto, Toronto, ON, M5S 1A8, Canada

    Sheena A. Josselyn & Paul W. Frankland

  6. Child & Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON, M5G 1M1, Canada

    Paul W. Frankland

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Contributions

RF: Conceptualization, Data Collection, Statistical Analysis, Writing (Original Draft), Writing (Editing). AIR: Data Collection, Statistical Analysis, Writing (Editing). AG: Data Collection, Writing (Editing). JDLP: Data Collection, Writing (Editing). YZ: Data Collection. AJM: Data Collection, Writing (Editing). SAJ: Supervision, Funding, Writing (Editing). PWF: Conceptualization, Supervision, Funding, Writing (Original Draft), Writing (Editing).

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Fujikawa, R., Ramsaran, A.I., Guskjolen, A. et al. Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02585-7

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