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Comments to behavioral tests for antidepressant-like actions of (2R,6R)–hydroxynorketamine by Bonaventura et al.

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Acknowledgements

This study was supported by a grant from the Japan Society for the Promotion of Science (to KH, 21H02846 and to LC, 22K15743).

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LC and KH conceived, drafted, and approved the final version of this work.

Corresponding author

Correspondence to Kenji Hashimoto.

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Competing interests

KH is the inventor of filed patent applications on “The use of R-ketamine in the treatment of psychiatric diseases”, “(S)-norketamine and salt thereof as pharmaceutical”, “R-ketamine and derivative thereof as prophylactic or therapeutic agent for neurodegeneration disease or recognition function disorder”, “Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases”, “R-ketamine and its derivatives as a preventive or therapeutic agent for a neurodevelopmental disorder”, and “TGF-β1 in the treatment of depression” by the Chiba University. KH has also received speakers’ honoraria, consultant fee, or research support from Abbott, Boehringer Ingelheim, Daiichi-Sankyo, Meiji Seika Pharma, Seikagaku Corporation, Sumitomo-Pharma, Taisho, Otsuka, Murakami Farm, and Perception Neuroscience. LC declares no conflict of interest.

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Chang, L., Hashimoto, K. Comments to behavioral tests for antidepressant-like actions of (2R,6R)–hydroxynorketamine by Bonaventura et al.. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01766-6

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  • DOI: https://doi.org/10.1038/s41380-022-01766-6

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