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Commentary on: “Host-parasite interaction associated with major mental illness”. Why we need integrative explanations based on evolutionary theory

Molecular Psychiatry volume 25, pages 2–3 (2020)Cite this article

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References

  1. Flegr J. How and why toxoplasma makes us crazy. Trends Parasitol 2013;29:156–63. https://doi.org/10.1016/j.pt.2013.01.007

    Article  PubMed  Google Scholar 

  2. Kano SI, Hodgkinson CA, Jones-Brando L, Eastwood S, Ishizuka K, Niwa M, et al. Host–parasite interaction associated with major mental illness. Mol Psychiatry. 2018. https://doi.org/10.1038/s41380-018-0217-z

  3. Webster JP, Kaushik M, Bristow GC, McConkey GA. Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? J Exp Biol 2013;216:99–112. https://doi.org/10.1242/jeb.074716

    Article  PubMed  PubMed Central  Google Scholar 

  4. Brüne M Schizophrenia as parasitic behavior manipulation: can we put together the pieces of an evolutionary puzzle? World Psychiatry. 2020. (in press).

  5. Parlog A, Schlüter D, Dunay IR. Toxoplasma gondii-induced neuronal alterations. Parasite Immun 2015;37:159–70.

    Article  CAS  Google Scholar 

  6. Howes O, McCutcheon R, Stone J. Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol 2015;29:97–115. https://doi.org/10.1177/0269881114563634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Coppens I, Dunn JD, Romano JD, Pypaert M, Zhang H, Boothroyd JC, et al. Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space. Cell 2006;125:261–74.

    Article  CAS  Google Scholar 

  8. Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 2011;12:707–22. https://doi.org/10.1038/nrn3120

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Niwa M, Cash-Padgett T, Kubo KI, Saito A, Ishii K, Sumitomo A, et al. DISC1 a key molecular lead in psychiatry and neurodevelopment: no-more disrupted-in-Schizophrenia 1. Mol Psychiatry 2016;21:1488–9. https://doi.org/10.1038/mp.2016.154

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Crespi B, Summers K, Dorus S. Adaptive evolution of genes underlying schizophrenia. Proc Biol Sci 2007;274:2801–10.

    Article  CAS  Google Scholar 

  11. Krause M, Theiss C, Brüne M. Ultrastructural alterations of von Economo neurons in the anterior cingulate cortex in schizophrenia. Anat Rec 2017;300:2017–24. https://doi.org/10.1002/ar.23635

    Article  Google Scholar 

  12. Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K, Erwin JM, et al. The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain Struct Funct. 2010;214:495–517.

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. LWL University Hospital Bochum, Department of Psychiatry, Psychotherapy and Preventive Medicine, Division of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Ruhr University Bochum, Bochum, Germany

    Martin Brüne

  2. Department of Cytology, Institute of Anatomy, Ruhr University Bochum, Bochum, Germany

    Carsten Theiss

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  1. Martin Brüne
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  2. Carsten Theiss
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Correspondence to Martin Brüne.

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Brüne, M., Theiss, C. Commentary on: “Host-parasite interaction associated with major mental illness”. Why we need integrative explanations based on evolutionary theory. Mol Psychiatry 25, 2–3 (2020). https://doi.org/10.1038/s41380-019-0541-y

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  • DOI: https://doi.org/10.1038/s41380-019-0541-y

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