Abstract

Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = −2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.

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Additional information

Members of the IMAGEN Consortium are listed below the Acknowledgements.

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Acknowledgements

This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behavior in normal brain function and psychopathology) (LSHM-CT- 2007-037286), the Horizon 2020 funded ERC Advanced Grant “STRATIFY” (Brain network based stratification of reinforcement-related disorders) (695313), ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) (PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) (MR/N027558/1), the FP7 projects IMAGEMEND (602450; IMAging GEnetics for MENtal Disorders) and MATRICS (603016), the Innovative Medicine Initiative Project EU-AIMS (115300-2), the Medical Research Council Grant “c-VEDA” (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the Swedish Research Council FORMAS, the Medical Research Council, the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, the Bundesministeriumfür Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; eMED SysAlc01ZX1311A; Forschungsnetz AERIAL 01EE1406A), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-1, SM 80/7-2, SFB 940/1). Further support was provided by grants from: ANR (project AF12-NEUR0008-01-WM2NA, and ANR-12-SAMA-0004), the Fondation de France, the Fondation pour la Recherche Médicale, the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012; the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), U.S.A. (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence.

Other IMAGEN Consortium members

Pausova Z., Mann K., Barker G.J., Lawrence C., Rietschel M., Robbins T.W., Williams S., Nymberg C., Topper L., Smith L., Havatzias S., Stueber K., Mallik C., Clarke T.K., Stacey D., Peng Wong C., Werts H., Williams S., Andrew C., Häke I., Ivanov N., Klär A., Reuter J., Palafox C., Hohmann C., Lüdemann K., Romanowski A., Ströhle A., Wolff E., Rapp M., Ihlenfeld A., Walaszek B., Schubert F., Connolly C., Jones J., Lalor E., McCabe E., NíShiothcháin A., Spanagel R., Sommer W., Steiner S., Buehler M., Stolzenburg E., Schmal C., Schirmbeck F., Heym N., Newman C., Huebner T., Ripke S., Mennigen E., Muller K., Ziesch V., Lueken L., Yacubian J., Finsterbusch J., Bordas N., Bricaud Z., Galinowski A., Gourlan C., Schwartz Y., Lalanne C., Barbot A., Thyreau B., Subramaniam N., Theobald D., Richmond N., de Rover M., Molander A., Jordan E., Robinson E., Hipolata L., Moreno M., Arroyo M., Stephens D., Ripley T., Crombag H., Lathrop M., Lanzerath D., Heinrichs B., Spranger T., Resch F., Haffner J., Parzer P., Brunner R., Constant P., Mignon X., Thomsen T., Vestboe A., Ireland J., Rogers J.

Author information

Affiliations

  1. Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    • Erin Burke Quinlan
    • , Sylvane Desrivières
    •  & Gunter Schumann
  2. Department of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, UK

    • Edward D. Barker
  3. Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, China

    • Qiang Luo
  4. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

    • Qiang Luo
  5. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany

    • Tobias Banaschewski
    • , Frauke Nees
    •  & Sarah Hohmann
  6. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland

    • Arun L. W. Bokde
  7. University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martini Street 52, 20246, Hamburg, Germany

    • Uli Bromberg
    •  & Christian Büchel
  8. Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany

    • Herta Flor
    •  & Frauke Nees
  9. Department of Psychology, School of Social Sciences, University of Mannheim, 68131, Mannheim, Germany

    • Herta Flor
  10. NeuroSpin, CEA, Université Paris-Saclay, 91191, Paris, France

    • Vincent Frouin
    •  & Dimitri Papadopoulos Orfanos
  11. Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, 05405, USA

    • Hugh Garavan
    •  & Bader Chaarani
  12. Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK

    • Penny Gowland
  13. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany

    • Andreas Heinz
    •  & Henrik Walter
  14. Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

    • Rüdiger Brühl
  15. Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes, Paris, France

    • Jean-Luc Martinot
  16. Maison de Solenn, Paris, France

    • Marie-Laure Paillère Martinot
  17. Pitié-Salpêtrière Hospital, Paris, France

    • Marie-Laure Paillère Martinot
  18. Rotman Research Institute, Baycrest, Toronto, ON, M6A 2E1, Canada

    • Tomáš Paus
  19. Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada

    • Tomáš Paus
  20. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold Street 5, 37075, Göttingen, Germany

    • Luise Poustka
  21. Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany

    • Michael N. Smolka
    •  & Juliane H. Fröhner
  22. School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland

    • Robert Whelan

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  1. IMAGEN Consortium

    Conflict of interest

    T.B. has served as an advisor or consultant to Bristol-Myers Squibb, Desitin Arzneimittel, Eli Lilly, Medice, Novartis, Pfizer, Shire, UCB, and Vifor Pharma; he has received conference attendance support, conference support, or speaking fees from Eli Lilly, Janssen McNeil, Medice, Novartis, Shire, and UCB; and he is involved in clinical trials conducted by Eli Lilly, Novartis, and Shire; the present work is unrelated to these relationships. E.D.B. has received funding for a PhD student and honoraria for teaching on scanner programming courses from General Electric Healthcare; he acts as a consultant for IXICO. H.W. received a speaker honorarium from Servier (2014). The remaining authors declare that they have no conflict of interest.

    Corresponding author

    Correspondence to Erin Burke Quinlan.

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    DOI

    https://doi.org/10.1038/s41380-018-0297-9