This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Data availability
The data are publicly available and accessible at https://cibmtr.org/CIBMTR/Resources/Publicly-Available-Datasets.
References
Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J, et al. Development of an unrelated donor selection score predictive of survival after HCT: donor age matters most. Biol Blood Marrow Transplant. 2018;24:1049–56.
Logan BR, Maiers MJ, Sparapani RA, Laud PW, Spellman SR, McCulloch RE, et al. Optimal donor selection for hematopoietic cell transplantation using Bayesian machine learning. JCO Clin Cancer Inform. 2021;5:494–507.
Alousi AM, Le-Rademacher J, Saliba RM, Appelbaum FR, Artz A, Benjamin J, et al. Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer? Blood. 2013;121:2567–73.
Guru Murthy GS, Kim S, Hu ZH, Estrada-Merly N, Abid MB, Aljurf M, et al. Relapse and disease-free survival in patients with myelodysplastic syndrome undergoing allogeneic hematopoietic cell transplantation using older matched sibling donors vs younger matched unrelated donors. JAMA Oncol. 2022;8:404–11.
Abid MB, Estrada-Merly N, Zhang MJ, Chen K, Bredeson C, Allan D, et al. Younger matched unrelated donors confer decreased relapse risk compared to older sibling donors in older patients with B cell acute lymphoblastic leukemia undergoing allogeneic hematopoietic cell transplantation. Transplant Cell Ther. 2023;29:611–8.
Bolon YT, Atshan R, Allbee-Johnson M, Estrada-Merly N, Lee SJ. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR summary slides, 2022. https://cibmtr.org/CIBMTR/Resources/Summary-Slides-Reports.
Bolanos-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, et al. Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis. N Engl J Med. 2023;388:2338–48.
CIBMTR. 2023. https://cibmtr.org/CIBMTR/Resources/Publicly-Available-Datasets#. Accessed 9 June 2023.
Gooptu M, Romee R, St, Martin A, Arora M, Al Malki M, Antin JH, et al. HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis. Blood. 2021;138:273–82.
Ustun C, Chen M, Kim S, Auletta JJ, Batista MV, Battiwalla M, et al. Post-transplantation cyclophosphamide is associated with increased bacterial infections. Bone Marrow Transplant. 2024;59:76–84.
Acknowledgements
We thank the CIBMTR staff for providing this dataset. The CIBMTR is supported primarily by the Public Health Service U24CA076518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); 75R60222C00011 from the Health Resources and Services Administration (HRSA); N00014-21-1-2954 and N00014-23-1-2057 from the Office of Naval Research.
Funding
This dataset was collected by the Center for International Blood and Marrow Transplant Research (CIBMTR) which is supported primarily by the Public Health Service U24CA076518 from the National Cancer Institute; the National Heart, Lung, and Blood Institute; the National Institute of Allergy and Infectious Diseases; 75R60222C00011 from the Health Resources and Services Administration; N00014-21-1-2954 and N00014-23-1-2057 from the Office of Naval Research; the National Marrow Donor Program/Be The Match; and the Medical College of Wisconsin.
Author information
Authors and Affiliations
Contributions
RSM conceptualized the study, performed the analysis, interpreted data, and wrote the manuscript; JR, PK, UP, REC, KR, and EJS reviewed and interpreted the data, reviewed the manuscript, and provided critical feedback. RSM had full access to the raw data which is publicly available. All authors approved the manuscript. The corresponding author had the final responsibility to submit for publication.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Ramdial, J., Kebriaei, P., Champlin, R.E. et al. Improved survival with younger HLA-matched unrelated donors versus older matched sibling donor HCT with PTCy-prophylaxis. Leukemia (2024). https://doi.org/10.1038/s41375-024-02256-0
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41375-024-02256-0