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MYELODYSPLASTIC NEOPLASM

Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms

Leukemia volume 38, pages 923–924 (2024)Cite this article

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In a letter to the editor, Oelschlaegel et al. [1] describes the new flow cytometry score (MDS-PB13) for the diagnosis of myelodysplastic syndromes (MDS) that relies on aberrant antigen expression of thirteen parameters in different cell populations of peripheral blood with 79–81% specificity and 61–70% sensibility.

Suspicion of MDS is the commonest reason for bone marrow aspirate and biopsy in older patients. Many individuals are unnecessarily exposed to discomfort and potential harms of these invasive procedures [2], because of the relatively limited prevalence of disease among those referred for suspected MDS [3]. Therefore, an objective assay based on a peripheral blood sample that accurately discriminates MDS from other unexplained cytopenia etiologies is warranted [4].

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References

  1. Oelschlaegel U, Winter S, Sockel K, Epp K, Schadt J, Röhnert MA, et al. MDS-PB13 score—blood based detection of aberrancies by flow cytometry in patients with suspected and confirmed myelodysplastic neoplasms. Leukemia. 2024;38:446–50.

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Authors and Affiliations

  1. Laboratoire d’immunologie, Université Grenoble Alpes, Grenoble University Hospital, Grenoble, France

    Tatiana Raskovalova & Marie-Christine Jacob

  2. Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France

    Tatiana Raskovalova, Marie-Christine Jacob & Sophie Park

  3. Service d’Hématologie, Université Grenoble Alpes, Grenoble University Hospital, Grenoble, France

    Sophie Park

Authors
  1. Tatiana Raskovalova
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  2. Marie-Christine Jacob
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  3. Sophie Park
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Contributions

TR and M-CJ developed the protocol and drafted the initial manuscript. SP contributed to critical revision of the manuscript. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Tatiana Raskovalova.

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Competing interests

Becton Dickinson Bioscience provided antibodies free of charge. The authors declare no competing interests relevant to this study.

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Raskovalova, T., Jacob, MC. & Park, S. Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms. Leukemia 38, 923–924 (2024). https://doi.org/10.1038/s41375-024-02223-9

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  • DOI: https://doi.org/10.1038/s41375-024-02223-9

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