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Chronic lymphocytic leukemia

IgA hypogammaglobulinemia predicts outcome in chronic lymphocytic leukemia

Leukemia volume 33, pages 1519–1522 (2019)Cite this article

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To the Editor,

Reduction of serum immunoglobulins (Ig) is the most common immune defect in chronic lymphocytic leukemia (CLL) with an incidence at diagnosis of 20–60% according to previous studies. Hypogammaglobulinemia worsens during the course of the disease and is probably due to the defective functioning of the non-clonal, CD5-negative B cells [1, 2].

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Authors and Affiliations

  1. Hematology Unit, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    G. Reda, R. Cassin, B. Fattizzo, M. Barbieri, S. Fabris, A. Neri, W. Barcellini & A. Cortelezzi

  2. Hematology Unit, Department of Onco-hematology, A.O. Cosenza, Cosenza, Italy

    M. Gentile

  3. Hematology, Department of Cellular Biotechnologies and Hematology, ‘Sapienza’ University, Rome, Italy

    F. R. Mauro

  4. Biostatistic Unit, Regina Elena National Institute for Cancer Treatment and Research, Rome, Italy

    D. Giannarelli

  5. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy

    I. Silvestris, A. Neri & A. Cortelezzi

  6. Hemato-oncology Department, Augusta Victoria Hospital, Mount of Olives, Jerusalem, Israel

    F. Morabito

  7. Biotechnology Research Unit, Aprigliano, Cosenza, Italy

    F. Morabito

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  1. G. Reda
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Correspondence to G. Reda.

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Reda, G., Cassin, R., Gentile, M. et al. IgA hypogammaglobulinemia predicts outcome in chronic lymphocytic leukemia. Leukemia 33, 1519–1522 (2019). https://doi.org/10.1038/s41375-018-0344-1

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