This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Amson R, Sigaux F, Przedborsk S, Flandrin G, Givols D, Telerman A. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. PNAS. 1989;86:8857–61.
Alvarado Y, Giles FJ, Swords R. The PIM kinases in hematological cancers. Exp Rev Hematol. 2012;5:81–96.
Brault L, Gasser C, Bracher F, Huber K, Knapp S, Schwaller J. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica. 2010;95:1004–15.
Garcia PD, Langowski JL, Wang Y, Chen M, Castillo J, Fanton C, et al. Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014;20:1834–45.
Keeton EK, McEachern K, Dillman KS, Palakurthi S, Cao Y, Grondine MR, et al. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 2014;123:905–13.
Lin Y-W, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010;115:824–33.
Gorello P, La Starza R, Di Giacomo D, Messina M, Puzzolo MC, Crescenzi B, et al. SQSTM1-NUP214: a new gene fusion in adult T-cell acute lymphoblastic leukemia. Haematologica. 2010;95:2161–3.
La Starza R, Borga C, Barba G, Pierini V, Schwab C, Matteucci C, et al. Genetic profile of T-cell acute lymphoblastic leukemia with MYC translocations. Blood. 2014;124:3577–82.
Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Belver L, Wendorff AA, et al. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014;20:1130–7.
Raimondi SC, Pui CH, Behm FG, Williams DL. 7q32–q36 translocation in childhood T cell leukemia: cytogenetic evidence for involvement of the T cell receptor b-chain gene. Blood. 1987;69:131–4.
Flaherty R, Smith A, Castaldi P. Second case of t(6;7) in acute lymphoblastic leukemia. Cancer Genet Cytogenet. 1999;112:188–9.
Chiaretti S, Messina M, Tavolaro S, Zardo G, Elia L, Vitale A, et al. Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223. Haematologica. 2010;95:1114–21.
Funding
This work was supported by: AIRC (IG-15525), Sergio Luciani Association, Fabriano, and Fondazione Cassa di Risparmio Perugia (2016.0113.021) to CM; AIRC Special Program Molecular Clinical Oncology-Extension program, 5 × 1000, (10007), to RF; Associazione Daniele Chianelli, Perugia, to RLS; Finanziamento per l’avvio alla ricerca 2015 (Sapienza University) to MM.
Author contributions
Conception and design: RLS; development of methodology: RLS, MM, VG, CM; molecular and cytogenetic studies: VP, TP, MZL, VG, MM; data analysis and interpretation: RLS, MM, VG, TP, GR, CM; writing and review of the manuscript: RLS, CM, MM, VG, SC, AV, RF.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
These authors contributed equally: RL Starza and M Messina.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
La Starza, R., Messina, M., Gianfelici, V. et al. High PIM1 expression is a biomarker of T-cell acute lymphoblastic leukemia with JAK/STAT activation or t(6;7)(p21;q34)/TRB@-PIM1 rearrangement. Leukemia 32, 1807–1810 (2018). https://doi.org/10.1038/s41375-018-0031-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41375-018-0031-2
This article is cited by
-
UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression
Cell Death Discovery (2022)