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The relationship between severe hypertensive diseases of pregnancy and moderate-severe bronchopulmonary dysplasia

Journal of Perinatology (2024)Cite this article

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Abstract

Objective

Determine the association between severe hypertensive disease of pregnancy (HDP) with moderate-severe bronchopulmonary dysplasia (BPD) in preterm infants (< 31 weeks’ gestation).

Study Design

Preterm birth cohort study of 693 mother-infant dyads. Severe HDP was defined as severe preeclampsia, HELLP syndrome or eclampsia. The outcome was moderate-severe BPD classified at 36 weeks corrected gestational age, per the NICHD Consensus statement.

Results

225 (32%) mothers developed severe HDP and 234 (34%) infants had moderate-severe BPD. There was an interaction between severe HDP and gestational age (p = 0.03). Infants born at < 25 weeks gestation to mothers with HDP had increased odds for moderate-severe BPD compared to infants of normotensive mothers delivering at the same gestational age. Infants born > 28 weeks to mothers with severe HDP had decreased odds for the outcome, though not statistically significant.

Conclusions

Severe HDP has a differential effect on the development of moderate-severe BPD based on gestational age.

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Fig. 1: Probability of moderate-severe BPD for infants born from normotensive mothers and mothers with HDP by gestational age.
Fig. 2: Odds ratio estimates for the risk of moderate-severe BPD among infants of mothers with HDP compared to infants of normotensive mothers across gestational age.

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Data availability

A de-identified analytic dataset to replicate the reported study findings are available at Mendeley Data, V1, https://doi.org/10.17632/b8trr3xh37.1.

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Acknowledgements

The authors acknowledge the generous institutional support by the University of Colorado Department of Ophthalmology and Pediatric Ophthalmology for the multidisciplinary team of the Colorado Retinopathy of Prematurity (CO-ROP) Research Group. Presentations: Presented in part at the Pediatric Academic Societies (PAS) Meeting, May 6-7, 2017, San Francisco, CA.

Funding

This project was supported in part by the Colorado Clinical and Translational Sciences Institute (CCTSI). The CCTSI is supported in part by the Colorado Clinical and Translational Science Award (CTSA) Grant UL1 TR002535, KL2 TR002534, and TL1 TR002533 from NCATS/NIH.

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Authors and Affiliations

  1. University of Colorado School of Medicine, Department of Pediatrics, Section of Neonatology, Aurora, CO, USA

    Erica M. Wymore & John P. Kinsella

  2. Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA

    Anne M. Lynch, Jasleen K. Singh, Tamara S. Thevarajah & Emily Auer

  3. Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA

    Jennifer K. Hodges

  4. Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA

    Brandie D. Wagner

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  1. Erica M. Wymore
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Contributions

EMW designed the study, data analysis and interpretation, wrote and finalized the manuscript. AML designed and supervised the study, data analysis, and finalization of the manuscript. TST and EA performed data abstraction and managed the database. JKS, JKH and JPK provided content expertize for study design, data interpretation and the manuscript. BDW developed the statistical analysis and interpretation and finalized the manuscript.

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Correspondence to Erica M. Wymore.

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Wymore, E.M., Lynch, A.M., Singh, J.K. et al. The relationship between severe hypertensive diseases of pregnancy and moderate-severe bronchopulmonary dysplasia. J Perinatol (2024). https://doi.org/10.1038/s41372-024-01910-w

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