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Safety of bubble nasal intermittent positive pressure ventilation (NIPPV) versus bubble nasal continuous positive airway pressure (NCPAP) in preterm infants with respiratory distress

Journal of Perinatology (2024)Cite this article

Subjects

Abstract

Objective

Nasal Intermittent Positive Pressure Ventilation (NIPPV) is an effective therapy for infants in respiratory distress. We here report the safety of a novel, low-cost, non-electric bubble NIPPV device in comparison with bubble NCPAP.

Study design

At Paramitha Children’s Hospital (Hyderabad, India), preterm (n = 60) neonates with moderate respiratory distress were pragmatically allocated to bubble NCPAP (5–8 cm H2O) or bubble NIPPV (Phigh 8–12 cm H2O/Plow 5–8 cm H2O) based on staff and equipment availability. Primary outcomes to assess safety included clinically relevant pneumothorax, nasal septal necrosis, or abdominal distention.

Results

One patient in each arm developed minor nasal septal injury (grade 3 on NCPAP, grade 2 on NIPPV); no patients in either arm developed a clinically significant pneumothorax or abdominal distention.

Conclusion

The similar rates of nasal septal injury, pneumothorax and abdominal distention suggest that bubble NIPPV has a similar safety profile as bubble NCPAP for preterm infants in respiratory distress.

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Data availability

The dataset analyzed during the current study is available from the corresponding author on reasonable request.

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Acknowledgements

This data has previously been presented at PRESS (Department of Pediatrics, University of Minnesota).

Funding

Research reported in this publication was supported by the Thrasher Foundation and by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494.

Author information

Author notes

  1. These authors contributed equally: Stephen C. John, Mehak Garg

  2. These authors jointly supervised this work: Vineet Bhandari, Tina Slusher, Srinivas Murki.

Authors and Affiliations

  1. Department of Medicine-Pediatrics, University of Minnesota, Minneapolis, MN, USA

    Stephen C. John

  2. Department of Neonatology, Paramitha Women and Children’s Hospital, Hyderabad, India

    Mehak Garg, Praveen Rao & Srinivas Murki

  3. Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

    Mounika Muttineni & Tina Slusher

  4. Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN, USA

    Ann M. Brearley

  5. Division of Neonatology, Department of Pediatrics, The Children’s Regional Hospital at Cooper/Cooper Medical School of Rowan University, Camden, NJ, USA

    Vineet Bhandari

  6. Department of Pediatrics, Hennepin Healthcare, Minneapolis, MN, USA

    Tina Slusher

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  1. Stephen C. John
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  7. Tina Slusher
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  8. Srinivas Murki
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Contributions

Study Conception and Design (SJ, MG, VB, TS, SM), Data analysis (SJ, MG, MM, AB, PR, VB, TS, SM), Drafting of manuscript and approval of final manuscript (SJ, MG, MM, AB, PR, VB, TS, SM).

Corresponding author

Correspondence to Stephen C. John.

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Competing interests

SCJ is a co-inventor of bubble NIPPV technology and co-founder of AIM Tech Health.

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John, S.C., Garg, M., Muttineni, M. et al. Safety of bubble nasal intermittent positive pressure ventilation (NIPPV) versus bubble nasal continuous positive airway pressure (NCPAP) in preterm infants with respiratory distress. J Perinatol (2024). https://doi.org/10.1038/s41372-024-01904-8

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  • DOI: https://doi.org/10.1038/s41372-024-01904-8

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