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Fish oil-containing multicomponent lipid emulsion vs soy-based lipid emulsion and neurodevelopmental outcomes of children born < 29 weeks’ gestation

Journal of Perinatology volume 40, pages 1712–1718 (2020)Cite this article

Subjects

Abstract

Objective

To compare neurodevelopmental outcomes of extremely preterm children who received soy-medium chain triglycerides-olive-fish oil-containing lipid emulsion (SMOF-LE) vs soy-based LE.

Study design

We conducted a pre-post comparative cohort study of children born < 29 weeks’ gestation who received > 7 days of LE. Outcomes were mortality/significant neurodevelopmental impairment (NDI), mortality/any NDI, significant NDI, any NDI, and individual components of NDI.

Results

Among children with follow-up data (Intralipid: n = 340/442, 77%; SMOF-LE: n = 214/286, 75%), baseline characteristics were comparable except for postnatal steroids. There was no significant difference in death/significant NDI between groups. Adjusted odds of death/any NDI [0.68 (95% CI 0.48, 0.97)], any NDI [0.64 (95% CI 0.44, 0.93)] and Bayley-III language score < 85 and <70 were significantly lower in the SMOF-LE group.

Conclusions

In extremely preterm children, a change from soy-based LE to SMOF-LE was not associated with deleterious effect on neurodevelopmental outcomes and may have been associated with some improvement.

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Fig. 1: Flow diagram of study participants.

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Data availability

The datasets generated and analyzed during the current study are with the corresponding author and may be available on reasonable request.

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Acknowledgements

The authors thank Heather McDonald-Kinkaid, Ph.D., of the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital, Toronto, ON, Canada, for editorial support in preparing this paper. MiCare is supported by a Canadian Institutes of Health Research Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals.

Funding

No specific funding was received for the project described in this paper. PSS holds an Applied Research Chair in Reproductive and Child Health Services and Policy Research from the Canadian Institutes of Health Research (APR-126340).

Author information

Authors and Affiliations

  1. Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada

    Ranjit Torgalkar, Jyotsna Shah, Shruti Dave, Nastaran Ostad, Kirsten Kotsopoulos, Sharon Unger, Edmond Kelly & Prakesh S. Shah

  2. Maternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada

    Junmin Yang & Prakesh S. Shah

  3. Department of Pediatrics, University of Toronto, Toronto, ON, Canada

    Prakesh S. Shah

Authors
  1. Ranjit Torgalkar
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  7. Sharon Unger
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Contributions

RT and PSS conceptualized and designed the study, drafted the initial paper, and reviewed and revised the paper. JS, SD, NO, KK, SU, and EK participated in study design and data interpretation and reviewed and revised the paper. JY analyzed the data and reviewed and revised the paper. All authors approved the final paper as submitted and agree to be accountable for all aspects of the work including ensuring that questions related to its accuracy or integrity are appropriately investigated and resolved.

Corresponding author

Correspondence to Prakesh S. Shah.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Sinai Health Research Ethics Board, Toronto, ON, Canada.

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Torgalkar, R., Shah, J., Dave, S. et al. Fish oil-containing multicomponent lipid emulsion vs soy-based lipid emulsion and neurodevelopmental outcomes of children born < 29 weeks’ gestation. J Perinatol 40, 1712–1718 (2020). https://doi.org/10.1038/s41372-020-0710-5

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