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Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study

Journal of Perinatology volumeĀ 39,Ā pages 1118ā€“1124 (2019)Cite this article

Subjects

Abstract

Objective

To examine the effectiveness of soybean oil-medium chain triglycerides-olive oil-fish oil lipid emulsion (SMOF-LE) on clinical outcomes of very-low-birth-weight neonates.

Study design

We conducted a pre-post comparative study of very-low-birth-weight neonates, dividing them according to lipid emulsion received: Intralipid (soy-based; nā€‰=ā€‰680) or SMOF-LE (nā€‰=ā€‰617). Primary outcomes were mortality, chronic lung disease, severe retinopathy, infection, and necrotising enterocolitis. Secondary outcomes were cholestasis, osteopenia, time to full feeds, and time to regain birthweight.

Results

Baseline characteristics between groups were comparable. Primary outcomes did not differ significantly between groups, although any retinopathy was significantly lower in the SMOF-LE group. SMOF-LE group had lower odds of cholestasis, osteopenia, and lipid interruption, and reduced times to full feeds and to regain birthweight.

Conclusions

Compared with Intralipid, SMOF-LE was not associated with differences in mortality and major morbidities but was associated with lower odds of any retinopathy, cholestasis, and osteopenia; and improved lipid tolerance.

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Acknowledgements

We thank Junmin Yang, MSc for help in statistical analyses and Sarah Hutchinson, PhD and Heather McDonald Kinkaid, PhD at the Maternal-Infant Care (MiCare) Research Centre at Mount Sinai Hospital in Toronto, Ontario, Canada, for providing editorial assistance in preparing this manuscript. We also thank the Canadian Institutes of Health Research and the Ontario Ministry of Health and Long-Term Care for providing financial support to the MiCare Research Centre. PS is supported by an Applied Chair in Reproductive and Child Health Services and Policy Research from the Canadian Institutes of Health Research.

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Authors and Affiliations

  1. Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada

    Ranjit Torgalkar,Ā Shruti Dave,Ā Jyotsna Shah,Ā Nastaran Ostad,Ā Kirsten Kotsopoulos,Ā Sharon UngerĀ &Ā Prakesh S. Shah

  2. Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada

    Prakesh S. Shah

  3. Department of Pediatrics, University of Toronto, Ontario, Canada

    Prakesh S. Shah

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  1. Ranjit Torgalkar
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Contributions

RT and PS conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. SD, JS, SU, NO and KK participated in design, interpreted data, and reviewed and revised the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Correspondence to Prakesh S. Shah.

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Torgalkar, R., Dave, S., Shah, J. et al. Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study. J Perinatol 39, 1118ā€“1124 (2019). https://doi.org/10.1038/s41372-019-0425-7

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