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Changes in cerebral tissue oxygenation and fractional oxygen extraction with gestational age and postnatal maturation in preterm infants

Journal of Perinatology volume 41, pages 836–842 (2021)Cite this article

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Abstract

Objective

This study examined the correlation of cerebral tissue oxygen saturation (SctO2) and cerebral tissue fractional oxygen extraction (cFTOE) with gestational age (GA) and postnatal age over the first 28 days of life.

Study design

Preterm infants with birth weight (BW) <1500 g were monitored with near-infrared spectroscopy (NIRS) during the first 28 days of life. SctO2 and cFTOE measurements were analyzed using a linear mixed model.

Results

A total of 70 preterm infants were included. Mean SctO2 decreased with increasing GA; SctO2 was 76.4% and 74.6% in the first 24 h for infants 24 and 28-week GA, respectively. For infants born at 24 and 28 it decreased to 52.9% and 58.4% at 28 days of life, respectively. cFTOE increased with increasing GA and postnatal age.

Conclusions

There is an inverse relationship between SctO2 and gestational age and postnatal age but a direct relationship between cFTOE with GA and postnatal age.

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Fig. 1: Estimated cerebral tissue oxygen saturation through repeated modeling in 7-day intervals within the first 28 days of life.
Fig. 2: Estimated cerebral fractional tissue oxygen extraction through repeated modeling in 7-day intervals within the first 28 days of life.

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Author information

Authors and Affiliations

  1. Department of Neonatology, Cleveland Clinic Children’s Hospital, Cleveland, OH, USA

    Mohamed A. Mohamed & Hany Aly

  2. Department of Biostatistics and Bioinformatics, the George Washington University Milken Institute School of Public Health, Washington, DC, USA

    Michael J. Frasketi & Heather J. Hoffman

  3. The Labatt Family Heart Centre, the Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Safwat Aly

  4. Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Mohamed El-Dib

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  1. Mohamed A. Mohamed
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  5. Heather J. Hoffman
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Contributions

MAM conceptualized study design, supervised data collection and data analysis, drafted initial version of background, methods, and discussions, edited and reviewed results sections. He reviewed and revised the final manuscript for intellectual content. MJF carried out the statistical analyses, drafted initial version of methods and results sections. He reviewed and revised the manuscript for intellectual content. SA conceptualized study design, recruited subjects, and applied NIRS to participants, collected and compiled demographic, clinical and NIRS data. He reviewed and revised the final manuscript for important intellectual content. ME-D contributed to conceptualizing study design, supervised demographic, clinical, and NIRS data collection and critically reviewed the manuscript. HJH contributed to the development of the data analysis plan, supervised and approved data analysis and critically reviewed the manuscript. HA conceptualized study design, supervised data collection, and reviewed and revised the final manuscript for important intellectual content All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. All authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Mohamed A. Mohamed.

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Mohamed, M.A., Frasketi, M.J., Aly, S. et al. Changes in cerebral tissue oxygenation and fractional oxygen extraction with gestational age and postnatal maturation in preterm infants. J Perinatol 41, 836–842 (2021). https://doi.org/10.1038/s41372-020-00794-w

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