Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants

Abstract

Objective

Characterize frequency and volume of blood draws and transfusions in extremely low birth weight infants in the first 10 weeks of life.

Study design

We included infants with a birth weight <1000 g born 23 0/7–29 6/7 weeks gestational age (GA) and with a length of stay ≥10 weeks, admitted between 2014 and 2016 to a single neonatal intensive care unit.

Results

Of 54 infants, median (25th, 75th percentile) GA and birth weight were 25 weeks (24, 26) and 665 g (587, 822), respectively. Median number of blood draws per infant decreased from 57 (49, 65) in week 1 to 12 (8, 22) in week 10. Median volume of blood extracted was 83 mL (70, 97), and median number of blood transfusions was 8 (5, 10).

Conclusions

This cohort experienced a high number and volume of blood draws. Draw frequency and transfusions decreased over the first 10 weeks of life.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Colombatti R, Sainati L, Trevisanuto D. Anemia and transfusion in the neonate. Semin Fetal Neonatal Med. 2016;21:2–9.

    Article  Google Scholar 

  2. Juul S. Erythropoiesis and the approach to anemia in premature infants. J Matern Fetal Neonatal Med. 2012;25:97–9.

    CAS  PubMed  Google Scholar 

  3. Ringer SA, Richardson DK, Sacher RA, Keszler M, Churchill WH. Variations in transfusion practice in neonatal intensive care. Pediatrics. 1998;101:194–200.

    Article  CAS  Google Scholar 

  4. Obladen M, Sachsenweger M, Stahnke M. Blood sampling in very low birth weight infants receiving different levels of intensive care. Eur J Pediatr. 1988;147:399–404.

    Article  CAS  Google Scholar 

  5. Madan A, Kumar R, Adams MM, Benitz WE, Geaghan SM, Widness JA. Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants. J Perinatol. 2005;25:21–5.

    Article  Google Scholar 

  6. Blanchette VS, Zipursky A. Assessment of anemia in newborn infants. Clin Perinatol. 1984;11:489–510.

    Article  CAS  Google Scholar 

  7. Widness JA. Pathophysiology of anemia during the neonatal period, including anemia of prematurity. Neoreviews. 2008;9:e520.

    Article  Google Scholar 

  8. Madsen LP, Rasmussen MK, Bjerregaard LL, Nohr SB, Ebbesen F. Impact of blood sampling in very preterm infants. Scand J Clin Lab Investig. 2000;60:125–32.

    Article  CAS  Google Scholar 

  9. Lin JC, Strauss RG, Kulhavy JC, Johnson KJ, Zimmerman MB, Cress GA, et al. Phlebotomy overdraw in the neonatal intensive care nursery. Pediatrics. 2000;106:E19.

    Article  CAS  Google Scholar 

  10. Widness JA, Madan A, Grindeanu LA, Zimmerman MB, Wong DK, Stevenson DK. Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor. Pediatrics. 2005;115:1299–306.

    Article  Google Scholar 

  11. Maier RF, Sonntag J, Walka MM, Liu G, Metze BC, Obladen M. Changing practices of red blood cell transfusions in infants with birth weights less than 1000 g. J Pediatr. 2000;136:220–4.

    Article  CAS  Google Scholar 

  12. Sacher RA, Strauss RG, Luban NL, Feil M, Anstall HB, Barnes A Jr, et al. Blood component therapy during the neonatal period: a national survey of red cell transfusion practice, 1985. Transfusion. 1990;30:271–6.

    Article  CAS  Google Scholar 

  13. Carroll PD, Widness JA. Nonpharmacological, blood conservation techniques for preventing neonatal anemia–effective and promising strategies for reducing transfusion. Semin Perinatol. 2012;36:232–43.

    Article  Google Scholar 

  14. Horvath MM, Winfield S, Evans S, Slopek S, Shang H, Ferranti J. The DEDUCE Guided Query tool: providing simplified access to clinical data for research and quality improvement. J Biomed Inf. 2011;44:266–76.

    Article  Google Scholar 

  15. Olsen IE, Groveman SA, Lawson ML, Clark RH, Zemel BS. New intrauterine growth curves based on United States data. Pediatrics. 2010;125:e214–24.

    Article  Google Scholar 

  16. Alagappan A, Shattuck KE, Malloy MH. Impact of transfusion guidelines on neonatal transfusions. J Perinatol. 1998;18:92–7.

    CAS  PubMed  Google Scholar 

  17. Widness JA, Kulhavy JC, Johnson KJ, Cress GA, Kromer IJ, Acarregui MJ, et al. Clinical performance of an in-line point-of-care monitor in neonates. Pediatrics. 2000;106:497–504.

    Article  CAS  Google Scholar 

  18. Freise KJ, Widness JA, Veng-Pedersen P. Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants. J Pharm Exp Ther. 2010;332:229–37.

    Article  CAS  Google Scholar 

  19. Sisson TR, Lund CJ, Whalen LE, Telek A. The blood volume of infants. I. The full-term infant in the first year of life. J Pediatr. 1959;55:163–79.

    Article  CAS  Google Scholar 

  20. Simon TL, Alverson DC, AuBuchon J, Cooper ES, DeChristopher PJ, Glenn GC, et al. Practice parameter for the use of red blood cell transfusions: developed by the Red Blood Cell Administration Practice Guideline Development Task Force of the College of American Pathologists. Arch Pathol Lab Med. 1998;122:130–8.

    CAS  PubMed  Google Scholar 

  21. Jopling J, Henry E, Wiedmeier SE, Christensen RD. Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system. Pediatrics. 2009;123:e333–7.

    PubMed  Google Scholar 

  22. Wang YC, Chan OW, Chiang MC, Yang PH, Chu SM, Hsu JF, et al. Red blood cell transfusion and clinical outcomes in extremely low birth weight preterm infants. Pediatr Neonatol. 2017;58:216–22.

    Article  Google Scholar 

  23. Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Ducrocq S, et al. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008;300:60–70.

    Article  CAS  Google Scholar 

  24. Shahid S, Dutta S, Symington A, Shivananda S, McMaster University NICU. Standardizing umbilical catheter usage in preterm infants. Pediatrics. 2014;133:e1742–52.

    Article  Google Scholar 

  25. Mimica AF, dos Santos AM, da Cunha DH, Guinsburg R, Bordin JO, Chiba A, et al. A very strict guideline reduces the number of erythrocyte transfusions in preterm infants. Vox Sang. 2008;95:106–11.

    Article  CAS  Google Scholar 

  26. Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, et al. The Premature infants in need of transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr. 2006;149:301–7.

    Article  Google Scholar 

  27. Kinmond S, Aitchison TC, Holland BM, Jones JG, Turner TL, Wardrop CA. Umbilical cord clamping and preterm infants: a randomised trial. BMJ. 1993;306:172–5.

    Article  CAS  Google Scholar 

  28. Ibrahim HM, Krouskop RW, Lewis DF, Dhanireddy R. Placental transfusion: umbilical cord clamping and preterm infants. J Perinatol. 2000;20:351–4.

    Article  CAS  Google Scholar 

  29. Valieva OA, Strandjord TP, Mayock DE, Juul SE. Effects of transfusions in extremely low birth weight infants: a retrospective study. J Pediatr. 2009;155:331–7 e1.

    Article  Google Scholar 

  30. Franz AR, Pohlandt F. Red blood cell transfusions in very and extremely low birthweight infants under restrictive transfusion guidelines: is exogenous erythropoietin necessary? Arch Dis Child Fetal Neonatal Ed. 2001;84:F96–100.

    Article  CAS  Google Scholar 

  31. Ohls RK. The use of erythropoietin in neonates. Clin Perinatol. 2000;27:681–96.

    Article  CAS  Google Scholar 

  32. Widness JA, Seward VJ, Kromer IJ, Burmeister LF, Bell EF, Strauss RG. Changing patterns of red blood cell transfusion in very low birth weight infants. J Pediatr. 1996;129:680–7.

    Article  CAS  Google Scholar 

Download references

Funding:

MP-D received salary support from the National Institutes of Health (T32 HD 43029-14, PI: Benjamin).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to P. Brian Smith.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Puia-Dumitrescu, M., Tanaka, D.T., Spears, T.G. et al. Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants. J Perinatol 39, 1670–1675 (2019). https://doi.org/10.1038/s41372-019-0515-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-019-0515-6

This article is cited by

Search

Quick links