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Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury

Journal of Perinatology volume 38, pages 1431–1443 (2018)Cite this article

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Abstract

Intraventricular hemorrhage in the setting of prematurity remains the most common cause of acquired hydrocephalus. Neonates with progressive post-hemorrhagic hydrocephalus are at risk for adverse neurodevelopmental outcomes. The goal of this review is to describe the distinct and often overlapping types of brain injury in the preterm neonate, with a focus on neonatal hydrocephalus, and to connect injury on imaging to neurodevelopmental outcome risk. Head ultrasound and magnetic resonance imaging findings are described separately. The current state of the literature is imprecise and we end the review with recommendations for future radiologic and neurodevelopmental research.

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Acknowledgements

This project was supported by the Thomas Wilson Sanitarium For Children of Baltimore City awarded to Rebecca Dorner and Marilee Allen and the NIH T32 Training Grant (5T32HL125239-03) awarded to Rebecca Dorner.

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Authors and Affiliations

  1. Division of Perinatal-Neonatal Medicine, Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, MD, USA

    Rebecca A. Dorner & Marilee C. Allen

  2. Neurosciences Intensive Care Nursery, The Johns Hopkins School of Medicine, Baltimore, MD, USA

    Rebecca A. Dorner, Vera Joanna Burton, Marilee C. Allen, Shenandoah Robinson & Bruno P. Soares

  3. Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA

    Vera Joanna Burton

  4. Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA

    Vera Joanna Burton

  5. Division of Pediatric Neurology and Neurological Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA

    Shenandoah Robinson

  6. Russell H. Morgan Department of Radiology and Radiological Science, Division of Pediatric Radiology and Pediatric Neuroradiology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA

    Bruno P. Soares

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  1. Rebecca A. Dorner
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  2. Vera Joanna Burton
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  3. Marilee C. Allen
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Correspondence to Rebecca A. Dorner.

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Dorner, R.A., Burton, V.J., Allen, M.C. et al. Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury. J Perinatol 38, 1431–1443 (2018). https://doi.org/10.1038/s41372-018-0209-5

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  • DOI: https://doi.org/10.1038/s41372-018-0209-5

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