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Vitamin D and associated perinatal–neonatal outcomes among extremely low-birth-weight infants

Journal of Perinatology volume 38, pages 1318–1323 (2018)Cite this article

Subjects

Abstract

Objective

To evaluate vitamin D inadequacy among extremely low-birth-weight (ELBW, <1000 g) infants and the association between circulating vitamin D concentrations and perinatal–neonatal outcomes.

Study design

Prospective cohort study of ELBW infants in the neonatal ICU. Blood was collected within the first 3 days after birth after obtaining informed consent. Circulating 25-hydroxyvitamin D concentrations (25(OH)D) were quantified using liquid chromatography–tandem mass spectroscopy and classified as vitamin D deficient, insufficient, or adequate ( < 20, 20–30, or > 30 ng/mL, respectively). Associations between 25(OH)D and perinatal–neonatal outcomes were determined by multivariable regression, adjusted for covariates that differ in the bivariate analysis.

Results

Of the 60 ELBW infants enrolled, 13 (22%) were vitamin D deficient, 15 (25%) were insufficient, and 32 (53%) were adequate. 25(OH)D levels were positively associated with fetal growth restriction and prolonged rupture of the membranes.

Conclusions

Vitamin D inadequacy was frequent among ELBW infants. Circulating vitamin D concentrations were significantly associated with perinatal outcomes in this contemporary cohort.

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Acknowledgements

We acknowledge Itsuka Kurihara and Alison Migliori at the Women and Infants Hospital of Rhode Island for assistance in data collection, and Drs. Marilyn Escobedo and Rita Raman at the University of Oklahoma for their assistance.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Children’s Hospital, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Birju A. Shah & Edgardo Szyld

  2. Department of Pediatrics, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA

    Birju A. Shah & James F. Padbury

  3. Department of Biostatistics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Michael P. Anderson

  4. Department of Medicine, Boston University Medical Center, Boston, MA, USA

    Michael F. Holick

  5. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Catherine M. Gordon

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  1. Birju A. Shah
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Correspondence to Birju A. Shah.

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Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Portions of the study were presented at the annual meeting of the Pediatric Academic Societies, San Francisco, CA, May 6–9 2017.

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Shah, B.A., Padbury, J.F., Anderson, M.P. et al. Vitamin D and associated perinatal–neonatal outcomes among extremely low-birth-weight infants. J Perinatol 38, 1318–1323 (2018). https://doi.org/10.1038/s41372-018-0203-y

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