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Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study

Journal of Perinatology volume 38, pages 1205–1211 (2018)Cite this article

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Abstract

Objective

To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants.

Study design

We conducted a retrospective observational tissue Doppler echocardiographic study over the first 12 h of age for infants born <32 weeks who were invasively ventilated, and infants on continuous positive pressure ventilation (CPAP).

Results

One hundred and eighty-three infants were included (27 ± 2 weeks and 999 ± 296 g). Invasively ventilated infants [(n = 96 (53%)] had lower left ventricular (LV) e‘ (3.4 ± 1.0 vs. 4.1 ± 1.5 cm/s, p < 0.01) and lower LV ea‘ ratio (0.8 ± 0.2 vs. 1.0 ± 0.4, p < 0.01), even after adjusting for common neonatal confounders (LV e‘ adjusted OR 0.62, 95% CI 0.45 – 0.87, p < 0.01; LV ea‘ adjusted OR 0.14, 95% CI 0.03–0.68, p = 0.01).

Conclusion

LV diastolic dysfunction is independently associated with a higher risk for invasive ventilation on day one of age.

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Funding

This study was funded by a grant from the Temple Street Hospital Foundation (Grant Reference RPAC 16–03); and the Rotunda Hospital Foundation (Ref: FoR /EQUIPMENT /101572).

Author contributions

NB wrote the first draft of this manuscript. No honorarium, grant, or any other form of payment was given to her or any other person to produce this manuscript. All authors listed made a substantial contribution to the conception and design of the work, the acquisition, analysis and interpretation of data. All authors revised the paper critically for important intellectual content and provided final approval of the version published. All authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Authors and Affiliations

  1. Department of Neonatology, The Rotunda Hospital, Dublin, Ireland

    Neidin Bussmann, Colm Breatnach, Naomi McCallion & Afif EL-Khuffash

  2. National Children’s Research Centre, Dublin, Ireland

    Neidin Bussmann & Colm Breatnach

  3. Department of Pediatrics, Washington University School of Medicine, St Louis Missouri, USA

    Philip T. Levy

  4. Department of Paediatrics, School of Medicine Royal College of Surgeons in Ireland, Dublin, Ireland

    Naomi McCallion & Afif EL-Khuffash

  5. Department of Paediatric Cardiology Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland

    Orla Franklin

Authors
  1. Neidin Bussmann
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  4. Naomi McCallion
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  6. Afif EL-Khuffash
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Corresponding author

Correspondence to Afif EL-Khuffash.

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The authors declare that they have no conflict of interest.

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Bussmann, N., Breatnach, C., Levy, P.T. et al. Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study. J Perinatol 38, 1205–1211 (2018). https://doi.org/10.1038/s41372-018-0147-2

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