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Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis

Journal of Human Hypertension volume 38, pages 187–190 (2024)Cite this article

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Infertility treatment is a risk factor for hypertensive disorders of pregnancy (HDP) [1, 2]. In Japan, more women are expected to undergo infertility treatment owing to the expansion of health insurance and the recent trend of women getting married late. Advanced maternal age is also an independent risk factor for HDP [3]. A systematic review revealed that advanced maternal age confounds the association between assisted reproductive technology (ART) and hypertension in pregnancy [4]. Whether infertility treatment is associated with HDP regardless of age should be investigated further. Thus, in this study, we examined the association between infertility treatment and HDP according to patient age.

In 2023, eight birth cohort studies participate in the Japan Birth Cohort Consortium (JBiCC) [5]. The details of JBiCC are described previously [6]. Four cohort studies were included in this meta-analysis because they collected information on maternal age, fertility treatment, and HDP. The Hamamatsu Birth Cohort for Mothers and Children (HBC Study) recruited 1 258 pregnant women in Hamamatsu, Shizuoka between 2007–2012. The Hokkaido Cohort included 20 926 pregnant women in Hokkaido between 2003–2012. The Babies and their Parents’ Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) study included 1 576 pregnant women in Sendai, Miyagi between 2006–2011. Lastly, the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study recruited 22 493 pregnant women in Miyagi Prefecture between 2013–2017. Written informed consent was obtained from all participants of each cohort, and the study protocol was approved by the Ethical Committee of the National Center of Child Health Development. Participants who withdrew from the study and those that had multiple pregnancies, a history of chronic hypertension, or missing information on infertility treatment, HDP, or maternal age were excluded from each cohort study.

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Fig. 1: Meta-analyses for the association between infertility treatment and HDP.

Data availability

Aggregated data used in this study is available upon request.

References

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Acknowledgements

We appreciate the participants and other stakeholders who supported the study.

Funding

Funding

This work was supported by the Japan Agency for Medical Research and Development (AMED, Japan) (JP17km0105001, JP21tm0124005, and JP19gk0110039).

Author information

Authors and Affiliations

  1. Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan

    Mami Ishikuro, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami & Shinichi Kuriyama

  2. Research Center for Child Mental Development, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu city, Shizuoka, 431-3192, Japan

    Tomoko Nishimura, Md. Shafiur Rahman & Kenji J. Tsuchiya

  3. Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan

    Hiroyoshi Iwata, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita & Reiko Kishi

  4. Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1, Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan

    Hirohito Metoki

  5. Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

    Keiko Tanaka & Yoshihiro Miyake

  6. Department of Social Medicine, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Kazue Ishitsuka & Naho Morisaki

  7. Division of Endocrinology and Metabolism, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Reiko Horikawa

  8. Center for Preventive Medical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Midori Yamamoto, Kenichi Sakurai & Chisato Mori

  9. Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Chisato Mori

  10. Iwate Tohoku Medical Megabank Organization, Iwate Medical University, 1-1-1, Idaidori, Yahaba-cho, Shiwa-gun, Iwate, 028-3694, Japan

    Atsushi Shimizu

  11. Health Center, Chuo University, 1-18, Ichigayatamachi, Shinjuku-ku, Tokyo, 162-8478, Japan

    Fumihiro Sata

Authors
  1. Mami Ishikuro
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  2. Tomoko Nishimura
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  3. Hiroyoshi Iwata
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  4. Hirohito Metoki
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  5. Taku Obara
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  6. Noriyuki Iwama
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  7. Keiko Murakami
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  8. Md. Shafiur Rahman
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  11. Chihiro Miyashita
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  12. Keiko Tanaka
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  13. Yoshihiro Miyake
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  14. Kazue Ishitsuka
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  15. Reiko Horikawa
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  16. Naho Morisaki
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  17. Midori Yamamoto
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  18. Kenichi Sakurai
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  19. Chisato Mori
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  20. Atsushi Shimizu
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  22. Kenji J. Tsuchiya
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  23. Reiko Kishi
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  24. Shinichi Kuriyama
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Consortia

the Japan Birth Cohort Consortium

  • Mami Ishikuro
  • , Tomoko Nishimura
  • , Hiroyoshi Iwata
  • , Hirohito Metoki
  • , Taku Obara
  • , Noriyuki Iwama
  • , Keiko Murakami
  • , Md. Shafiur Rahman
  • , Maki Tojo
  • , Sumitaka Kobayashi
  • , Chihiro Miyashita
  • , Keiko Tanaka
  • , Yoshihiro Miyake
  • , Kazue Ishitsuka
  • , Reiko Horikawa
  • , Naho Morisaki
  • , Midori Yamamoto
  • , Kenichi Sakurai
  • , Chisato Mori
  • , Atsushi Shimizu
  • , Fumihiro Sata
  • , Kenji J. Tsuchiya
  • , Reiko Kishi
  •  & Shinichi Kuriyama

Contributions

MI: Conceptualization, Methodology, Data curation, Formal analysis, Investigation, Writing– original draft. TN: Methodology, Data curation, Formal analysis, Investigation, Writing– Review and editing. HI: Methodology, Data curation, Formal analysis, Investigation, Writing– Review and editing. HM: Methodology, Data curation, Formal analysis, Investigation, Writing– Review and editing, Project administration. TO: Conceptualization, Methodology, Supervision, Writing– Review and editing, Project administration. NI: Methodology, Resources, Writing– Review and editing. KM: Methodology, Resources, Writing– Review and editing. M.S R: Methodology, Resources, Writing– Review and editing. MT: Methodology, Resources, Writing– Review and editing. S Kobayashi: Methodology, Resources, Writing– Review and editing. C Miyashita: Methodology, Resources, Writing– Review and editing. KT: Methodology, Resources, Writing– Review and editing. YM: Methodology, Writing– Review and editing, Project administration. KI: Methodology, Writing– Review and editing, Project administration. RH: Methodology, Resources, Writing– Review and editing, Project administration. NM: Methodology, Writing– Review and editing, Project administration. MY: Methodology, Resources, Writing– Review and editing. KS: Methodology, Resources, Writing– Review and editing. C Mori: Methodology, Writing– Review and editing, Project administration. AS: Methodology, Writing– Review and editing, Project administration. FS: Methodology, Writing– Review and editing, Project administration. K J.T: Methodology, Writing– Review and editing, Project administration. RK: Methodology, Writing– Review and editing, Project administration. S Kuriyama: Methodology, Supervision, Writing– Review and editing, Project administration.

Corresponding author

Correspondence to Taku Obara.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics approval and consent to participate

Written informed consent was obtained from all participants of each cohort, and the study protocol was approved by the Ethical Committee of the National Center of Child Health Development.

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Cite this article

Ishikuro, M., Nishimura, T., Iwata, H. et al. Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis. J Hum Hypertens 38, 187–190 (2024). https://doi.org/10.1038/s41371-023-00890-2

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  • DOI: https://doi.org/10.1038/s41371-023-00890-2

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