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Two heart failure phenotypes in arterial hypertension: a clinical study

Journal of Human Hypertension volume 32, pages 460–462 (2018)Cite this article

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The Original Article was published on 02 April 2018

Arterial hypertension is the most prevalent comorbidity in Heart Failure with Preserved Ejection Fraction (HFpEF) [1]. The new HFpEF paradigm proposed has shifted emphasis to endothelial alterations, which lower myocardial Nitric Oxide bioavailability and removes the brake on prohypertrophic stimuli triggered by myocardial afterload excess. The development of HFpEF has been linked to microvascular involvement of the coronary vascular bed [2, 3].

In arterial hypertension it has long been recognized that retinal vascular changes parallel the associated end-organ damage, mainly the “hypertensive cardiomyopathy” or the concentric left ventricular hypertrophy due to chronic afterload. Retinal arteriolar narrowing, is seen to correlate strongly with the severity of coronary artery lesions and reduced myocardial perfusion indices on cardiac MRI [4].

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Authors and Affiliations

  1. Department Of Cardiology, University of Florence, Florence, Italy

    Fabio Fantini

  2. Department Of Cardiology, SJMCH, Bangalore, India

    Srilakshmi M. Adhyapak & Kiron Varghese

  3. Department Of Ophthalmology, SJMCH, Bangalore, India

    Mary Varghese

  4. Division of Epidemiology and Biostatistics, SJRI, Bangalore, India

    Tinku Thomas

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  1. Fabio Fantini
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Correspondence to Srilakshmi M. Adhyapak.

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Fantini, F., Adhyapak, S.M., Varghese, K. et al. Two heart failure phenotypes in arterial hypertension: a clinical study. J Hum Hypertens 32, 460–462 (2018). https://doi.org/10.1038/s41371-017-0017-y

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