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Epidemiology and Population Health

The role of body mass index on the association between the energy-adjusted dietary inflammatory index and hyperuricemia: a mediation analysis based on NHANES (2007–2016)

International Journal of Obesity volume 48, pages 339–345 (2024)Cite this article

Subjects

Abstract

Background

The Energy-Adjusted Dietary Inflammatory Index (E-DII) is related to both body mass index (BMI) and hyperuricemia. However, the association among BMI, hyperuricemia and DII is yet to be fully elucidated. The purpose of this study is to explore the role of BMI in the relationship between E-DII and hyperuricemia in the American population.

Methods

A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016, with a sample size of 10,571 participants. The study used a weighted logistic regression model and a generalized additive model (GAM) to explore the associations among BMI, hyperuricemia and E-DII. Furthermore, mediation analysis was utilized to illustrate the mediating relationships among these variables.

Results

The results of the study indicated that a higher E-DII was related to an increased risk of hyperuricemia. The association between E-DII and hyperuricemia was partially mediated by BMI.

Conclusions

E-DII is associated with hyperuricemia. BMI mediates the relationship between E-DII and hyperuricemia among Americans, which provides crucial information for the prevention of hyperuricemia.

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Fig. 1
Fig. 2
Fig. 3: Associations between E-DII, BMI and HUA using GAM models.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Author notes

  1. These authors contributed equally: Qingzhen He, Qingzhao Zheng.

Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, 1163 Xinmin Avenue, Changchun, 130021, P. R. China

    Qingzhen He, Qingzhao Zheng, Houze Diao, Mingyuan Li, Qing Zhu, Fang Fang & Weiwei Cui

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Contributions

We thank all participants and all investigators. QH, QZ and HD wrote and reviewed the manuscript; WC and FF made the study design; QH, QZ, HD, ML and QZ conducted the study and analyzed the data; All authors read and approved the final manuscript.

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Correspondence to Fang Fang or Weiwei Cui.

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He, Q., Zheng, Q., Diao, H. et al. The role of body mass index on the association between the energy-adjusted dietary inflammatory index and hyperuricemia: a mediation analysis based on NHANES (2007–2016). Int J Obes 48, 339–345 (2024). https://doi.org/10.1038/s41366-023-01418-x

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