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Clinical Research

Resistin/uric acid index as a marker of metabolic syndrome in females with obesity

International Journal of Obesity volume 47, pages 393–398 (2023)Cite this article

Subjects

Abstract

Background

The resistin/uric index has been considered a prognostic factor for identifying young people with obesity. Obesity and Metabolic Syndrome (MS) are an important health problem in females.

Aims

The objective of this work was to evaluate the relationship of resistin/acid uric index with Metabolic Syndrome on Caucasian females with obesity.

Methods

We conducted a cross sectional study in 571 females with obesity. Measurements of anthropometric parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C reactive protein, uric acid, resistin and prevalence of Metabolic Syndrome were determined. The resistin/uric acid index was calculated.

Results

In total, 249 subjects had MS (43.6%). We detected higher levels in the following parameters (Delta; p values); waist circumference (3.1 ± 0.5 cm; p = 0.04), systolic blood pressure (5.3 ± 3.6 mmHg; p = 0.01), diastolic blood pressure (2.3 ± 0.4 mmHg; p = 0.02), glucose levels (7.5 ± 0.9 mg/dL; p = 0.01), insulin levels (2.5 ± 0.3 UI/L; p = 0.02), HOMA-IR (0.7 ± 0.2 units; p = 0.03), uric acid levels (0.9 ± 0.2 mg/dl; p = 0.01), resistin levels (4.1 ± 0.4 ng/dl; p = 0.01) and resistin/uric acid index (0.61 ± 0.01 mg/dl; p = 0.02) in subjects of the high resistin/uric acid index group than low index group. Logistic regression analysis reported a high percentage of hyperglycemia (OR = 1.77, 95% CI = 1.10–2.92; p = 0.02), hypertension (OR = 1.91, 95% CI = 1.36–3.01; p = 0.01), central obesity (OR = 1.48, 95% CI = 1.15–1.84; p = 0.03) and metabolic syndrome percentage (OR = 1.71, 95% CI = 1.22–2.69; p = 0.02) in high resistin/uric acid index group.

Conclusions

Resistin/uric acid index is related with Metabolic syndrome (MS) risk and criteria of it in a population of Caucasian females with obesity and this index is a correlated with glucose levels, insulin levels and insulin resistance (HOMA-IR).

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Data availability

All data generated or analyzed during this study are included in this article. Further enquiries can be directed to the corresponding author.

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Author information

Authors and Affiliations

  1. Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain

    David Primo & Olatz Izaola

  2. Investigation Centre on Endocrinology and Nutrition (IEN), University of Valladolid, Valladolid, Spain

    David Primo, Olatz Izaola & Daniel de Luis

Authors
  1. David Primo
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  2. Olatz Izaola
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  3. Daniel de Luis
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Contributions

DdeL designed the study an wrote the article. OI, realized nutritional evaluation. DP and DdeL realized biochemical evaluation.

Corresponding author

Correspondence to Daniel de Luis.

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The authors declare no competing interests.

Ethics statement

This study protocol was reviewed and approved by [HCVUA Commitee], approval number [No 6/2018] Written Informed consent was obtained from all individual participants included in the study.

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Signed informed consent was otained in all participants. This research comply with the guidelines for human studies in accordance with the World Medical Association Declaration of Helsinki.

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Primo, D., Izaola, O. & de Luis, D. Resistin/uric acid index as a marker of metabolic syndrome in females with obesity. Int J Obes 47, 393–398 (2023). https://doi.org/10.1038/s41366-023-01287-4

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