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Genetic variation in populations from central Argentina based on mitochondrial and Y chromosome DNA evidence

Journal of Human Geneticsvolume 63pages493507 (2018) | Download Citation

Abstract

We present new data and analysis on the genetic variation of contemporary inhabitants of central Argentina, including a total of 812 unrelated individuals from 20 populations. Our goal was to bring new elements for understanding micro-evolutionary and historical processes that generated the genetic diversity of the region, using molecular markers of uniparental inheritance (mitochondrial DNA and Y chromosome). Almost 76% of the individuals show mitochondrial lineages of American origin. The Native American haplogroups predominate in all surveyed localities, except in one. The larger presence of Eurasian maternal lineages were observed in the plains (Pampas) of the southeast, whereas the African lineages are more frequent in northern Córdoba. On the other hand, the analysis of 258 male samples reveals that 92% of them present Eurasian paternal lineages, 7% carry Native American haplogroups, and only 1% of the males show African lineages. The maternal lineages have high genetic diversity homogeneously distributed throughout central Argentina, probably as result of a recent common origin and sustained gene flow. Migratory events that occurred in colonial and recent times should have contributed to hiding any traces of differentiation that might have existed in the past. The analysis of paternal lineages showed also homogeneous distribution of the variation together with a drastic reduction of the native male population.

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Acknowledgements

We especially thank the participants for their cooperation with our work during the collection of biological samples. Thanks are due to the Mariana Fabra and Pierre Luisi for useful comments on the manuscript. Angelina García, Graciela Bailliet, Claudio Bravi, and Darío Demarchi are Research Career Member of the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina (CONICET). This investigation was funded by ANPCyT through grants PICT 2012-711 and by SECyT (Universidad Nacional de Córdoba).

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Affiliations

  1. Instituto de Antropología de Córdoba (IDACOR), CONICET/Universidad Nacional de Córdoba, 5000, Córdoba, Argentina

    • Angelina García
    • , Maia Pauro
    •  & Darío A. Demarchi
  2. Laboratorio de Genética Molecular Poblacional, IMBICE (CIC-PBA, CCT- CONICET), CC 403, 1900, La Plata, Argentina

    • Graciela Bailliet
    •  & Claudio M. Bravi

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The authors declare that they have no conflict of interest.

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Correspondence to Angelina García.

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https://doi.org/10.1038/s10038-017-0406-7