(Pro)renin receptor
Song and colleagues examined temporal expression of the (pro)renin receptor ((P)RR) during organogenesis in mice. Investigators found that (P)RR gene and protein expression in the brain, kidney, heart, and lung is developmentally regulated in a tissue-specific manner.
Hyperactive airways
Choi and coinvestigators sought to determine whether the priming effect of intra-amniotic lipopolysaccharide (LPS) amplifies hyperoxia-induced airway hyperreactivity (AHR) in rat pups. LPS was injected into the amniotic cavities of pregnant rats, and rat pups were exposed to 60% O2 for 14 days after birth. On postnatal day 14, it was found that LPS had indeed amplified postnatal hyperoxia-induced AHR.
See Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats
Hyperoxic lung injury
Bronchopulmonary dysplasia (BPD) is an important cause of morbidity among preterm newborns. Cetinkaya et al. evaluated the preventive effect of cytidine 5′-diphosphocholine (CDP choline) on hyperoxic lung injury in a neonatal rat model. Severe hyperoxia-induced lung damage was significantly ameliorated by CDP-choline treatment, suggesting that this may be a novel therapeutic option for the prevention of BPD.
See Cytidine 5′-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model
Imaging and brain maturation
Natalucci and coauthors hypothesized that early amplitude-integrated electroencephalogram (aEEG) values correlate with brain maturation and injury score assessed by conventional magnetic resonance imaging (MRI) at term-equivalent age. The results of their study show that the average aEEG total maturity score and its cycling subscore were positively and significantly associated with total MRI maturation score.
Spectroscopy and the preterm brain
Magnetic resonance spectroscopy enables noninvasive study of brain metabolism and may thus provide useful information about brain injury. Card and colleagues identified associations of brain metabolite ratios in very preterm infants with white matter lesions and overall health status at birth. They found that both overall health status and white matter injury are reflected in metabolite ratios measured shortly after birth.
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Editor’s Focus. Pediatr Res 74, 1 (2013). https://doi.org/10.1038/pr.2013.75
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DOI: https://doi.org/10.1038/pr.2013.75