Poster Presentations: Neonatology - Other | Published:

Poster Presentations: Neonatology - Other

Endogenous Stress Response on Pentatonic Music in Very Low Birthweight Infants

Pediatric Research volume 70, page 724 (2011) | Download Citation


Background: Music exposition of prematures has previously been reported to reduce pain, improve vital signs and result in overall non-specific “well-being”. Valid data on endogenous stress hormone response to music, determined by salivary cortisol levels, are scarce.

Objective: The aim of this study was to test the effect of live pentatonic music on the ambient stress level of very low birthweight infants.

Methods: Stable infants (birthweight 500 - 1500 g, mean age: 22 days, n=16) were exposed to 15 minutes of live harp music on 3 consecutive days, at the same time of the day. Music was identically played on a kantele. Saliva was collected prior to music exposition and at defined time points after music. Salivary cortisol and cortisone levels were measured by liquid-chromatography-tandem-mass-spectrometry and salivary cortisol additionally by ELISA (n=10).

Stress levels were additionally assessed by recordings of heart rate, respiratory rate and oxygen saturation. Pain level was determined by Bernese-Pain-Scale-for-Neonates (BSN).

Results: Salivary cortisol decreased from baseline to 25 minutes and 4 hours after intervention on all 3 days (p < 0.05 on day 1 and 3). Apneas, the number of desaturations as well as BSN levels improved significantly on all 3 days (p< 0.05).

Conclusion: Our findings indicate that pentatonic music exposition can decrease stress hormone levels of preterm neonates in a NICU environment. These are the first data regarding the effect of music exposition on stress hormone levels in a sufficient cohort of VLBW infants supporting a positive effect of music on these infants.

Author information


  1. Division of Neonatology, Ludwig-Maximilian-University Munich-Grosshadern, Munich, Germany

    • D Schwilling
    • , F Schwaiblmair
    • , A Schulze
    •  & A W Flemmer
  2. Institute of Clinical Chemistry, Ludwig-Maximilian-University Munich-Grosshadern, Munich, Germany

    • M Vogeser
    •  & F Kirchhoff


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