Abstract
Background: Optimal timing of cMRI after therapeutic hypothermia is controversial.
Aim: To compare cMRI postnatal d4 with d10.
Methods: Sagittal/axial T1 IR-weighted and axial T2-weighted images were visual scored: Basal ganglia and thalami (DNGM), white (WM), cortical gray matter (CGM) 0-3 (0=normal, 1=mild, 2=moderate, 3=severe), posterior limb of capsula interna (PLIC) 0-2 (0=normal, 1=equivocal, 2=loss), haemorrhages 0-2 (0=none, 1=extra-axial, 2=intracerebral).
Rusults: Twenty-five infants (GA 36-41) were examined
Eighteen had normal; seven had abnormal scans on d4 and d10. Five had mild to severe changes in DNGM d4, two progressed from mild to moderate on d10. Two grade 1 CGM progressed to grade 2 or 3 on d10. Two without CGM pathology d4 had mild to moderate on d10. Three had grade 2 or 3 WM findings; one regressed from grade 3 to 2. Four had abnormal PLIC on d4, two disappeared d10. Two had haemorrhages on d4 and d10; grade 2 (data not shown in the tbl)
Conclusions: CGM and DNGM lesions progressed from day d4 to day d10, WM and PLIC regressed slightly from d4 to d10.
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Skranes, J., Stiris, T., Alonso, A. et al. Comparison of Conventional Cerebral MRI (CMRI) at Day 4 and 10 after Perinatal Hypoxic-Ischemic Encephalopathy Treated with Hypothermia. Pediatr Res 70 (Suppl 5), 213 (2011). https://doi.org/10.1038/pr.2011.438
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DOI: https://doi.org/10.1038/pr.2011.438