The CTNS gene appears to be actively regulated at the transcriptional and post-transcriptional levels and might play a pivotal role in regulating cell thiol concentrations.
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Use of stool colonocytes might be a valuable noninvasive approach for studying gut pathophysiology in newborns.
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Chronic hypoxia resulted in long-term impairment of hippocampal neurogenesis and was mediated, in part, by attenuation of the mammalian target of rapamycin (mTOR) pathway.
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Mildly dysrhythmic thalamocortical interactions may contribute to altered spontaneous cortical activity in children born very preterm.
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Near-infrared spectroscopy (NIRS) and transcranial Doppler ultrasound (TCD) revealed that pulsatile flow might have advantages over non-pulsatile flow in children undergoing cardiopulmonary bypass for congenital heart defect repair, which might help improve post-operative outcome.
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Children exposed to high levels of cocaine in utero appear to exhibit blunted nighttime cortisol increases.
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Editor's Focus. Pediatr Res 70, i (2011). https://doi.org/10.1203/PDR.0b013e3182291b13
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DOI: https://doi.org/10.1203/PDR.0b013e3182291b13