Abstract
Introduction: Unintended propylene glycol (PG) administration (34 mg/kg/24h) did not affect postnatal adaptations [1]. Subsequently, we aim to document PG disposition in neonates.
Methods: Blood and urine samples were collected in neonates to whom PG was co-administered (Paracetamol Synthetica®, Mendrisio, Italy). Plasma and urine samples were collected in the first six hours after the first drug administration (loading dose, 20 mg.kg1 paracetamol, equal to 16 mg PG kg-1). An earlier described reversed phase liquid chromatographic (LC) method with ultraviolet detection was optimized for chromatographic separation.
Results: Chromatographic separation resulted in cleaner chromatograms without interfering compounds. Linearity, variations in the intra-and inter-assay precision and accuracy and stability at different temperature conditions were satisfactory. The lower limit of quantification (0.25 mg.L-1) was twenty times lower than in earlier described methods. The method was suitable for quantification of PG concentrations in low volume plasma (15-46 mg.L-1) and urine samples (20-175 mg.L-1), strongly indicating difference between neonates and adults in the relative contribution of the renal (7.02%) compared to the metabolic route for PG elimination. Assuming a one-compartment model, peak concentrations were around 40 mg.L-1, suggesting a distribution volume of 0.5 L.kg-1 while the elimination half life was estimated to be 6-12 h.
Conclusion: An accurate and sensitive LC method was developed, and applied to determine PG in low volume neonate plasma and urine samples, enabling us to estimate the renal versus non-renal contribution of PG clearance in neonates.
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Allegaert K et al. Arch Dis Child 2010; 95: 1054–1058
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Kulo, A., Cossey, V., De Hoon, J. et al. Propylene Glycol Pharmacokinetics and Renal Elimination Capacity: Preliminary Observations. Pediatr Res 70 (Suppl 5), 846 (2011). https://doi.org/10.1038/pr.2011.1071
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DOI: https://doi.org/10.1038/pr.2011.1071