Abstract
Background and aims: The effect of early surfactant treatment is uncertain. The aim of this study was to evaluate mortality and moderate/severe BPD in relation to timing of surfactant treatment.
Methods: All 452 admitted infants with gestational age (GA) ≤ 30 weeks from a national cohort of infants with GA 220-276 weeks and/or birth weight (BW) 500-999 g were studied.
Results. Only minor differences in mortality or BPD was found between infants given surfactant in delivery room (S-DR) only, NICU (S-NICU) only or both in DR and in NICU (S-DR/NICU) (Table 1).
Surfactant missing for 23 infants in entire cohort, for 17 infants in BPD cohort
*p < 0.05 versus S-DR and S-NICU, #p < 0.05 versus DR, §p < 0.05 versus S-NICU
Conclusions: Infants with a high rate of surfactant treatment still have a high incidence of BPD. Timing of surfactant treatment has only minor effects on mortality and morbidity in extremely premature infants.
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Farstad, T., Bratlid, D. & and The Norwegian Extreme Premature Study Group. 513 Timing of Surfactant Treatment in Extremely Premature Infants - Effects on Mortality and Development of Bronchopulmonary Dysplasia (BPD). Pediatr Res 68 (Suppl 1), 262–263 (2010). https://doi.org/10.1203/00006450-201011001-00513
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DOI: https://doi.org/10.1203/00006450-201011001-00513