Abstract
Background: Optimal protein intake improves weight gain whereas sufficient intake of calcium (Ca) and Phosphate (P) is necessary for bone mineralization and gain in length.
Aims: Evaluation of long-term growth in relation to standard intake with low and higher amount of amino acids (AA), Ca, P.
Methods: consecutive cohort study (C1, C2) preterm infants with follow up until 24 months; standard parenteral intake: C1: max: 2.5g/kg/d AA, Ca/P: 1/0,26 mmol/kg/d C2: max: 3g/kg/d AA, Ca/P: 3/1,9 mmol/kg/d. Enteral feeding: not different, starting day 1; human milk fortification from 50ml/d on. Comparison between two cohorts: nutritional intake and growth during first five weeks, follow up at term corrected age (TCA), 6, 12 and 24 months. SDS for weight and length according to Dutch reference1,2.
Results: C1: Male: n = 28, GA 29.3 ±2.3, BW 1272 ± 351g. Female n = 29 GA28.8± 1.7, BW 1129± 319 C2: Male: n = 35 GA 29.5±1.9, BW 1325±359, Female n= 30, GA 29.4±3.6, BW 1272±340.
Conclusions: AGA infants demonstrated main catch up at 6 months after TCA with complete recovery for length in C2male. Male infants take more advantage from improved feeding regimen.
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References
Visser GHA Early Hum Dev 2009
Frederiks AM Ped Res 2000
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Christmann, V., Visser, R. 1058 Improved Catch Up Growth in Male Preterm Aga Infants with Increased Early Protein and Mineral Intake. Pediatr Res 68 (Suppl 1), 525–526 (2010). https://doi.org/10.1203/00006450-201011001-01058
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DOI: https://doi.org/10.1203/00006450-201011001-01058