Abstract 191

Objective. To study the impact of extreme PROM on neonatal outcome in VLBWI.

Methods. Retrospective analysis of all inborn infants [gestational age (GA) ≥24 wks, no major malformation] with PROM <25 of GA during 1990 to 1997. For statistical analysis (Fisher's exact test) only patients with PROM and a latency ≥7d (median 46d) and controls were matched for GA, birth weight and year. Results. PROM occurred in 110 pregnancies at 20.1 (13.7-24.8) wks. 55% reached a GA ≥24 wks [latency 14 (0-138)d]. 52/60 infants received neonatal care. GA: 25.7 (24.0-34.0) wks. 77% survived, mortality was caused in 6/12 infants by respiratory morbidity. 7/19 infants with PROM < 20 wks of GA survived without IVH > II°, BPD, ROP or NEC. (Table) Conclusion: 60 of 110 pregnancies were maintained after extreme PROM until ≥24 weeks of GA. There was only a trend to an increased morbidity in infants with PROM. Perinatal decision making and parental counceling should consider this data

Table 1 No caption available.
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