Abstract 40
Background. Recently we have shown that the course of neonatal RDS is complicated by inflammation and activation of clotting, local as well as systemic. (Pediatr Res 1996;39:456-63 and 1996;39:958-65) To investigate whether HFOV results in less activation than CV we studied ventilated preterm lambs.
Subjects and measurements. Lambs, delivered by caesarean section at 132 days gestational age (term 145 days) were ventilated for 8 hours by HFOV (n=8) or CV (n=8). 15 Minutes after birth and at 2 hour intervals thereafter blood samples were taken from umbilical catheters and broncho-alveolar lavage fluid (BALF) was collected.
Results. Elastase in BALF is equally low at birth and rises in the first 2 hours in both groups. Plasma β-glucuronidase is high at birth and decreases in both groups. See table for significant different results, mean and SEM are given.
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Jaarsma, A., Braaksma, M., Geven, W. et al. High Frequency Oscillatory Ventilation (HFOV) results in less activation of inflammation and clotting compared to Conventional Ventilation (CV) in the preterm lamb with neonatal RDS. Pediatr Res 45, 893 (1999). https://doi.org/10.1203/00006450-199906000-00058
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DOI: https://doi.org/10.1203/00006450-199906000-00058
