Abstract 115
Background: It has been suggested that inability to produce the anti-inflammatory cytokine IL-10 may predispose preterm infants to CLD1.
Aims: To measure IL-10 in bronchoalveolar lavage fluid from preterm infants.
Patients: 17 consecutive ventilated infants ≤ 29 weeks gestation on HFOV.
Measurements: Daily samples were analysed for IL-10 using an ELISA. CLD was defined as an oxygen requirement at 36 weeks corrected gestation.
Results: IL-10 was detectable at some point in all 17 infants. 9 of 11 survivors developed CLD. Their IL-10 (pg/ml) values are given below.Table
Conclusions: IL-10 is detectable in early bronchoalveolar lavage samples from ventilated preterm infants but does not prevent the development of CLD.
References
Jones et al 1996. Ped Res; 39: p966.
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Biermasz, N., McColm, J., Stenson, B. et al. Measurement of IL-10 in BAL Samples from Preterm Ventilated Infants. Pediatr Res 44, 438 (1998). https://doi.org/10.1203/00006450-199809000-00148
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DOI: https://doi.org/10.1203/00006450-199809000-00148
