Abstract 75
Background: We tested the hypothesis that increase of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) during hypoxia would be reduced by blocking the Endothelin-1 A and B receptors. Subjects: Twentyeight 1-2 d old piglets.
Intervention: Randomized to 3 groups : gr. 1 hypoxia (n=10), gr. 2 hypoxia with ET receptorblocker (ET bl.) 1 mg/kg (n=9), gr. 3 : hypoxia with ET-bl. 5 mg/kg (n=9). Hypoxia was induced by ventilation with 8% O2. When mean arterial blood pressure was <20 mm Hg or base deficit >20 mmol/L reoxygenation with room air was started.
Results: During hypoxia PAP increased in gr 1 and 2, unchanged in gr 3. PVR increased during hypoxia in all 3 groups. At 1 min of reoxygenation PAP increased in gr 3, unchanged in gr 1 and 2. At 5 min reoxygenation PAP was unchanged in gr 1 and 2, increased in gr 3. PVR decreased significantly in all groups at 1 and 5 min reoxygenation. Conclusions: ET-1 A and B receptors are involved in the changes of pulmonary hemodynamics during hypoxia and early reoxygenation.Table
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Medø, S., Tølløfsrud, P. & Saugstad, O. Pulmonary Circulation, Hypoxia and Reoxygenation With Room Air; Blocking of the Endothelin-1 Receptors in Piglets. Pediatr Res 44, 431 (1998). https://doi.org/10.1203/00006450-199809000-00108
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DOI: https://doi.org/10.1203/00006450-199809000-00108
