Aim: To evaluate the effect of combined resistive and elastic unloading (CUL) during spontaneous breathing, on tidal volume (Vt), respiratory rate (RR) and slowly adapting pulmonary stretch receptor (SAPSR) activity. Method: After lavage and subsequent replacement of surfactant, ventilation was altemated between CPAP (4.5-6.0 cm H2O) and combined unloading (resistance=20 cm H2O/L*s-1;elastance=0.4 cm H2O/mL) during spontaneous breathing. RR, Vt, respiratory system compliance(Cr), and both the number of SAPSR impulses and the instantaneous impulse frequency were measured.
Results: Table
Conclusion: Compared to the values obtained during CPAP both Vt and SAPSR increased significantly during CUL. A further increase was seen after surfactant replacement in these parameters indicating the influence of SAPSR activity on respiratory regulation.
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Sindelar, R., Dammann, V., Jonzon, A. et al. Combined Unloading Versus Cpap During Spontaneous Breathing in Surfactant Depleted Cats:Before and After Surfactant Replacement. Pediatr Res 42, 414 (1997). https://doi.org/10.1203/00006450-199709000-00197
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DOI: https://doi.org/10.1203/00006450-199709000-00197
