Effect of Surfactant or Liquid Ventilation With Rm 101 on Gas Exchange (Ge) and Lung Mechanics (Lm) in Nwb. Piglets

Background: 2 treatment strategies to compare GE and LM in artificial RDS after lavage (paO2 constantly < 13 kPa; lung compliance(Crs< ½ baseline, FiO2=1.0 and VT=5-10 ml/kg). Subjects: 13 newborn piglets (< 2 days: MW. 1708 g). Measurement of Crs. blood gases, systemic and pressure of respiratory system before (baseline), 0 and 60 min after injury and 15, 30, 60 and 120 min. after intervention: Randomized surfactant (n=7: Alveofact 100 mg/kg) or RM 101 (n=6; 2 ml/kg/min initially, reduced to 0.5 ml/kg/min) intratracheal via bypass-tube without disconnecting ventilation.

Results: Table

Table 1

Conclusion: 101 and Alveofact improved GE (↓ of OI and AaDO₂) and LM (↑ Crs). Increase was higher in Crs (p<0.05). visible by higher VT's (p<0.05) and PaO₂ (n.s) in RM 101 group, probably as result of higher peak insp. pressure and FRC.