BACKGROUND. Pulmonary inflammatory processes may be important in the pathogenesis of BPD.
SUBJECTS. To monitor pulmonary inflammation we followed concentrations of prostacyclin as 6-keto-prostaglandin (6-keto-PG) and thromboxane (TxB2) in a total of 145 tracheal aspirates from 20 intubated preterm infants (gest.age 27.6±2.2 wks) during the first week.
RESULTS. 13 patients developed BPD. In them pulmonary concentrations of 6-keto-PG and TxB2 were lower during d 4-7 than in 7 patients surviving without BPD (Fig).
Figure 1
CONCLUSION. Development of BPD may be associated with differences in pulmonary prostaglandin metabolism.
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Lassus, P., Ylikorkala, O., Viinikka, L. et al. Does Prostaglandins Protect Against the Development of Bronchopulmonary Dysplasia (Bpd)?. Pediatr Res 42, 413 (1997). https://doi.org/10.1203/00006450-199709000-00190
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DOI: https://doi.org/10.1203/00006450-199709000-00190
