Background: Granulocyte colony-stimulating factor (G-CSF) has been shown to induce neutrophilia and to enhance mature effector neutrophil function. Whereas serum concentrations of G-CSF are high during infection, nothing is known about G-CSF receptor (G-CSF-R) expression on neutrophils of neonates.
Subjecs: G-CSF-R expression was determined flow cytometrically(FACScan) with a polyclonal anti-G-CSF antibody stained with a monoclonal anti-IgG(Fc) antibody.
Results: Percentage of neutrophils expressing G-CSF-R neonates G-CSF -R expression on neutrophils was lower in infected neonates when compared with healthy controls. Table
Conclusion: G-CSF-R is downregulated during infection.
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Gessler, P., Boos, G., Nebe, T. et al. G-CSF receptor expression on neutrophils of healthy term and preterm neonates and in those with infection. Pediatr Res 42, 386 (1997). https://doi.org/10.1203/00006450-199709000-00025
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DOI: https://doi.org/10.1203/00006450-199709000-00025
